Effect of hydroalcoholic fruit extract of Persea americana Mill. on high fat diet induced obesity: A dose response study in rats.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high fat diet (HFD) | increase | weight gain | male Sprague Dawley rats | - | significant increase | #1 |
high fat diet (HFD) | increase | body mass index (BMI) | male Sprague Dawley rats | - | significant increase | #2 |
high fat diet (HFD) | increase | blood lipids | male Sprague Dawley rats | - | significant increase | #3 |
high fat diet (HFD) | increase | low density lipoproteins (LDL) | male Sprague Dawley rats | - | significant increase | #4 |
high fat diet (HFD) | increase | lipid peroxides (LPO) | male Sprague Dawley rats | - | significant increase | #5 |
high fat diet (HFD) | increase | serum transaminases | male Sprague Dawley rats | - | significant increase | #6 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | decrease | blood lipids | HFD+HAEPA fed rats | - | significant decrease | #7 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | decrease | LPO | HFD+HAEPA fed rats | - | significant decrease | #8 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | decrease | liver lipids | HFD+HAEPA fed rats | - | significant decrease | #9 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | increase | antioxidant status | HFD+HAEPA fed rats | - | increase | #10 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | decrease | fatty acid synthase | HAEPA co-administered rats | - | decreased significantly | #11 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | decrease | HMG CoA reductase | HAEPA co-administered rats | - | decreased significantly | #12 |
hydroalcoholic fruit extract of Persea americana (HAEPA) | increase | Lipoprotein lipase activity | HFD+HAEPA rats | - | found increased | #13 |
100 mg of HAEPA/kg body wt. | increase | hypolipidemic activity | - | - | exhibited optimum hypolipidemic activity | #14 |
The fruits of Persea Americana Mill., commonly known as Avocado, are traditionally consumed for various health benefits including weight reduction. Here, we studied the effect of hydroalcoholic fruit extract of Persea americana (HAEPA) on high fat diet (HFD) induced obesity in rats. Obesity was induced in male Sprague Dawley rats by feeding HFD for 14 wk. The hypolipidemic effect was evaluated by co-administering 25, 50, 100 and 200 mg/kg body wt. of HAEPA. There was a significant increase in weight gain, body mass index (BMI), blood lipids, low density lipoproteins (LDL), lipid peroxides (LPO) and serum transaminases in HFD fed rats. HFD+HAEPA fed rats showed a significant decrease in blood lipids, LPO, liver lipids and increase in antioxidant status when compared to HFD control rats. The activity of lipid metabolic key enzymes such as fatty acid synthase and HMG CoA reductase in liver were also found to be decreased significantly in HAEPA co-administered rats. Lipoprotein lipase activity was found increased in HFD+HAEPA rats. Among the 4 doses studied, 100 mg of HAEPA/kg body wt. exhibited optimum hypolipidemic activity. Histopathological observations in liver and visceral adipose tissue added more evidence for the lipid lowering effect of HAEPA. It can be concluded that avocado fruit extract can act as hypolipidemic agent probably by modulating the activities of HMG CoA reductase and fatty acid synthase in liver.