New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease.
Study Goal
The researchers aimed to review the pathogenic role of oxidative stress in chronic kidney disease and cardiovascular complications, and evaluate current antioxidant therapy options.
Results Summary
The study highlights oxidative stress as a key factor in kidney function decline and cardiovascular complications, discussing potential antioxidant therapies including vitamin D, pharmacologic treatments for hyperuricemia, and plant-based antioxidants. Some new therapy options in diabetic nephropathy, such as noninsulin antidiabetic agents and food components, were also reviewed.
Population
Patients with chronic kidney disease and associated cardiovascular complications, including those with diabetic nephropathy.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
antioxidant therapy | decrease | oxidative stress | chronic kidney disease | - | are discussed | #1 |
vitamin D | decrease | oxidative stress | chronic kidney disease | - | are discussed | #2 |
pharmacologic therapies for hyperuricemia | decrease | oxidative stress | chronic kidney disease | - | are discussed | #3 |
antidiabetic agents (noninsulin dependent) | decrease | diabetic nephropathy | - | - | are reviewed | #4 |
plant antioxidants | decrease | diabetic nephropathy | - | - | are reviewed | #5 |
food components | decrease | diabetic nephropathy | - | - | are reviewed | #6 |
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed. Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies.