Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats.
Study Goal
The researchers aimed to determine whether Caralluma fimbriata extract (CFE) could protect against high-fat diet-induced oxidative stress in the testes of rats.
Results Summary
CFE treatment prevented oxidative stress markers (lipid peroxidation, protein oxidation) and restored antioxidant levels in high-fat diet-fed rats, suggesting protective effects on testicular health. The study did not address long-term human applicability or potential side effects.
Population
Male Wistar rats (animal study).
Effective Dosage
200 mg/kg body weight, orally administered.
Duration
90 days.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
High-fat diet (HFD) | increase | oxidative stress formation | - | - | promotes | #1 |
High-fat diet (HFD) | decrease | reproductive system and fertility | - | - | has hazardous effects on | #2 |
Caralluma fimbriata extract (CFE) | decrease | high-fat diet-induced oxidative stress in the testis | rat | - | protective effect | #3 |
High-fat diet (HFD) | increase | lipid peroxidation | high-fat fed rats | - | showed higher levels of | #4 |
High-fat diet (HFD) | increase | protein oxidation | high-fat fed rats | - | showed higher levels of | #5 |
High-fat diet (HFD) | increase | polyol pathway enzymes | high-fat fed rats | - | showed higher levels of | #6 |
High-fat diet (HFD) | decrease | GSH | high-fat fed rats | - | showed lower levels of | #7 |
High-fat diet (HFD) | decrease | antioxidants | high-fat fed rats | - | showed lower activities of | #8 |
Caralluma fimbriata extract (CFE) | decrease | all these observed abnormalities | high-fat fed rats | - | prevented | #9 |
Caralluma fimbriata extract (CFE) | decrease | HF-diet induced testicular oxidative stress | rats | - | offers a significant protection against | #10 |
High-fat diet (HFD) promotes the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. The objective of this study was to evaluate the protective effect of Caralluma fimbriata on high-fat diet-induced oxidative stress in the testis of rat. Male Wistar rats were randomly divided into five groups: Control (C), Control treated with CFE (C+ CFE), High fat diet fed (HFD), High fat diet fed treated with CFE (HFD+CFE) and High fat diet fed treated with Metformin (HFD+Met). CFE was orally administered (200mg/kg body weight) for 90days to groups-C+CFE and HFD+CFE rats. The effects of HF-diet on the reproductive organs were determined by measuring relative and absolute testes and epididymal fat pads weights. Regarding testes antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation, polyol pathway enzymes and lower GSH levels and lower activities of antioxidants, while CFE treatment prevented all these observed abnormalities. The present study clearly indicates that CFE offers a significant protection against HF-diet induced testicular oxidative stress in rats.