Assessment of Adequacy of Supplementation of Vitamin D in Very Low Birth Weight Preterm Neonates: A Randomized Controlled Trial.
Study Goal
The researchers aimed to compare the effects of two different doses of vitamin D (400 IU/day vs. 1000 IU/day) on serum calcium and related biomarkers in very low birth weight preterm neonates.
Results Summary
The study found that 1000 IU/day of vitamin D significantly increased serum calcium and 25-OHD levels while reducing ALP and parathormone levels, with fewer cases of skeletal hypomineralization and better growth compared to 400 IU/day.
Population
Very low birth weight preterm neonates (n=50).
Effective Dosage
400 IU/day (Group 1) or 1000 IU/day (Group 2).
Duration
6 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D 1000 IU/day | increase | mean serum calcium levels | very low birth weight preterm neonates | p < 0.001 | significantly higher | #1 |
Vitamin D 1000 IU/day | increase | 25-hydroxy vitamin D (25-OHD) levels | very low birth weight preterm neonates | p < 0.001 | significantly higher | #2 |
Vitamin D 1000 IU/day | decrease | alkaline phosphatase (ALP) levels | very low birth weight preterm neonates | p < 0.001 | significantly lower | #3 |
Vitamin D 1000 IU/day | decrease | parathormone levels | very low birth weight preterm neonates | p < 0.001 | significantly lower | #4 |
Vitamin D 1000 IU/day | decrease | incidence of skeletal hypomineralization | very low birth weight preterm neonates | - | lesser | #5 |
Vitamin D 1000 IU/day | increase | growth | very low birth weight preterm neonates | - | better | #6 |
OBJECTIVES: To compare the effect of 400 IU and 1000 IU vitamin D for 6 weeks in very low birth weight preterm neonates. DESIGN: Randomized, double-blinded controlled trial in a teaching hospital. PARTICIPANTS: Fifty very low birth weight preterm neonates. INTERVENTION: Vitamin D 400 IU/day (Group 1) or 1000 IU/day (Group 2). OUTCOME MEASURES: Change in serum calcium, phosphate, alkaline phosphatase (ALP), 25-hydroxy vitamin D (25-OHD), parathormone, incidence of skeletal hypomineralization and growth. RESULTS: After 6 weeks of supplementation, the mean serum calcium and 25-OHD levels were significantly higher (p < 0.001 each), while ALP and parathormone levels significantly lower (p < 0.001 each) in group 2. Skeletal hypomineralization was lesser and growth better in group 2. CONCLUSION: Vitamin D supplementation in a dose of 1000 IU/day is more effective in maintaining serum calcium, phosphate, ALP, 25-OHD and parathormone levels with lower incidence of skeletal hypomineralization and better growth.