Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review.
Study Goal
The researchers aimed to evaluate the role of polyphenols as antioxidants in addressing benign prostatic hyperplasia (BPH) and prostate cancer (PCa), focusing on their effects on oxidative stress, cell cycle, and hormone function.
Results Summary
The abstract suggests that polyphenols may have a beneficial role in managing oxidative stress and influencing cell cycle and hormone function relevant to BPH and PCa, though evidence for BPH is limited compared to prostate cancer. Additional clinical trials or meta-analyses are needed for conclusive findings.
Population
Elderly individuals with or at risk of benign prostatic hyperplasia and prostate cancer.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
compounds with antioxidant action | neutral | symptoms and onset | patients with benign prostatic hyperplasia and prostate cancer | - | could affect | #1 |
Polyphenols | decrease | oxidative stress | - | - | appear to act | #2 |
Polyphenols | neutral | cell cycle and hormone function | - | - | seems to have a direct action | #3 |
Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.