Resistance Training and Co-supplementation with Creatine and Protein in Older Subjects with Frailty.
Study Goal
The researchers aimed to assess the feasibility, safety, and efficacy of co-supplementation with creatine and whey protein combined with resistance training in older individuals with frailty.
Results Summary
Both whey protein with creatine (WHEY+CR) and whey protein alone (WHEY) similarly improved muscle function, with no significant differences between groups. Body composition and blood parameters remained unchanged, and no severe adverse effects were observed.
Population
Older individuals with frailty.
Effective Dosage
Not specified in the abstract.
Duration
14 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) combined with resistance training | increase | handgrip | older individuals with frailty | WHEY+CR = 26.65 ± 31.29; WHEY = 13.84 ± 14.93 Kg | were similarly effective in improving | #1 |
whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) combined with resistance training | decrease | timed-up-and-go | older individuals with frailty | WHEY+CR = -11.20 ± 9.37; WHEY = -17.76 ± 21.74 sec | were similarly effective in improving | #2 |
whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) combined with resistance training | increase | timed-stands test | older individuals with frailty | WHEY+CR = 47.50 ± 35.54; WHEY = 46.87 ± 24.23 reps | were similarly effective in improving | #3 |
whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) combined with resistance training | no change | body composition | older individuals with frailty | - | were not changed | #4 |
whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) combined with resistance training | no change | blood parameters | older individuals with frailty | - | were not changed | #5 |
co-supplementation with creatine and whey protein | no change | adverse events | older subjects with frailty undertaking resistance training | - | was well-tolerable and free of adverse events | #6 |
creatine supplementation | no change | body composition | older subjects with frailty | - | did not augment the adaptive effects of resistance training along with whey protein on | #7 |
creatine supplementation | no change | muscle function | older subjects with frailty | - | did not augment the adaptive effects of resistance training along with whey protein on | #8 |
BACKGROUND: Studies assessing the effects co-supplementation with creatine and protein, along with resistance training, in older individuals with frailty are lacking. OBJECTIVES: This is an exploratory trial from the Pro-Elderly study ("Protein Intake and Resistance Training in Aging") aimed at gathering knowledge on the feasibility, safety, and efficacy of co-supplementation with creatine and protein supplementation, combined with resistance training, in older individuals with frailty. DESIGN: A 14-week, double-blind, randomized, parallel-group, placebo controlled exploratory trial. SETTING, PARTICIPANTS: The subjects were randomly assigned to whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) group. All subjects undertook a supervised exercise training program and were assessed at baseline and after 14 weeks. MEASUREMENTS: Muscle function, body composition, blood parameters, and self-reported adverse events were assessed. RESULTS: No interaction effects (between-group differences) were observed for any dependent variables (p > 0.05 for all). However, there were main time-effects in handgrip (WHEY+CR = 26.65 ± 31.29; WHEY = 13.84 ± 14.93 Kg; p = 0.0005), timed-up-and-go (WHEY+CR = -11.20 ± 9.37; WHEY = -17.76 ± 21.74 sec; p = 0.006), and timed-stands test (WHEY+CR = 47.50 ± 35.54; WHEY = 46.87 ± 24.23 reps; p = 0.0001), suggesting that WHEY+CR and WHEY were similarly effective in improving muscle function. All of the subjects showed improvements in at least two of the three functional tests, regardless of their treatments. Body composition and blood parameters were not changed (p > 0.05). No severe adverse effects were observed. CONCLUSIONS: Co-supplementation with creatine and whey protein was well-tolerable and free of adverse events in older subjects with frailty undertaking resistance training. Creatine supplementation did not augment the adaptive effects of resistance training along with whey protein on body composition or muscle function in this population. Clinicaltrials.gov: NCT01890382.