Vitamin D, bone metabolism and fracture risk.
Study Goal
The researchers aimed to determine the role of vitamin D and calcium supplementation in reducing fracture risk and regulating bone remodeling.
Results Summary
The study found that vitamin D, when administered at doses above 800 IU/day alongside adequate calcium supplementation, positively affects fracture risk and bone remodeling, provided serum 25OHD levels exceed 30 ng/mL.
Population
Compliant patients with insufficient serum levels of 25OH vitamin D.
Effective Dosage
Above 800 IU/day of vitamin D with adequate calcium supplementation.
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | decrease | fracture risk | compliant patients | - | has positive effects | #1 |
daily doses above 800 UI/d | decrease | positive effects on fracture risk | compliant patients | above 800 UI/d | consistently observed | #2 |
adequate calcium supplementation | decrease | positive effects on fracture risk | compliant patients | - | together with | #3 |
serum 25OHD levels above 30 ng/mL | decrease | positive effects on fracture risk | compliant patients | above 30 ng/mL | achieved biological target | #4 |
Insufficient serum levels of 25OH vitamin D (25OHD) is a risk factor for osteoporosis. A new paradigm has emerged with the locally synthesized 1,25(OH)2D within osteoblasts and osteoclasts as the essential pathway for the effects of 25OHD in regulating bone remodeling via direct or indirect activation of the specific receptor VDR. Vitamin D has positive effects on fracture risk but these results have been consistently observed whenever daily doses were above 800 UI/d administered to compliant patients together with adequate calcium supplementation and with an achieved biological target of serum 25OHD levels above 30 ng/mL.