Metabolic effects of vitamin D supplementation in vitamin D deficient patients (a double-blind clinical trial).
Study Goal
The researchers aimed to determine whether correcting vitamin D deficiency improves insulin sensitivity and blood sugar control.
Results Summary
Vitamin D supplementation significantly increased vitamin D levels and improved insulin sensitivity, leading to reduced fasting insulin, 2-h insulin, and HOMA indices, maintaining glucose in the normal range with lower insulin levels.
Population
210 people with vitamin D deficiency
Effective Dosage
50,000 units per week
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D (50,000 units per week) | increase | Vitamin D levels | people with vitamin D deficiency | 13.7±5.2 unit increase versus 0.8±2.8 | significantly increased | #1 |
vitamin D (50,000 units per week) | decrease | fasting insulin levels | people with vitamin D deficiency | 6.8±8.1 unit reduction versus 2.3±3.7 | lead to significant changes | #2 |
vitamin D (50,000 units per week) | decrease | 2-h insulin | people with vitamin D deficiency | 31.1±34.9 unit reduction versus 4.5±24.6 | lead to significant changes | #3 |
vitamin D (50,000 units per week) | decrease | Homeostasis Model Assessment (HOMA) indices | people with vitamin D deficiency | - | lead to significant changes | #4 |
Correction of vitamin D deficiency | increase | insulin sensitivity | people with vitamin D deficiency | - | leads to increased | #5 |
Correction of vitamin D deficiency | no change | glucose | people with vitamin D deficiency | in the normal range | significantly able to maintain | #6 |
Correction of vitamin D deficiency | decrease | insulin | people with vitamin D deficiency | - | lower levels | #7 |
BACKGROUND: Vitamin D has recently been given a lot of attention for its role in controlling insulin secretion. Many studies have spoken of its role in weight management, blood sugar control and many other metabolic variables. PATIENT AND METHODS: In a randomized double-blind clinical trial, 210 people with vitamin D deficiency were randomly allocated into two groups receiving vitamin D (50,000 units per week) or placebo for 8 weeks. RESULTS: Vitamin D levels were significantly increased in the group receiving vitamin D supplementation (13.7±5.2 unit increase versus 0.8±2.8). The increased levels of vitamin D lead to significant changes in fasting insulin levels (6.8±8.1 unit reduction versus 2.3±3.7), a 2-h insulin (31.1±34.9 unit reduction versus 4.5±24.6) and Homeostasis Model Assessment (HOMA) indices. CONCLUSION: Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range with lower levels of insulin.