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Caffeine and cardiovascular diseases: critical review of current research.

European journal of nutrition
June 1, 2016
Anthony Zulli et al. (15 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review the safety, proposed benefits, and side effects of caffeine consumption, particularly from energy drinks, and identify safe dosage levels.

Results Summary

The study highlights concerns about caffeine safety and its effects on alertness, performance, and cardiovascular health, noting inconsistent results due to varying populations, doses, and study designs.

Population

Humans and animal models (not specified further).

Effective Dosage

Not specified.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
caffeine
increase
alertness
-
-
proposed beneficial role
#1
caffeine
increase
performance
-
-
proposed beneficial role
#2
caffeine
increase
energy expenditure
-
-
proposed beneficial role
#3
caffeine
neutral
cardiovascular system
-
-
side effects
#4
Abstract

Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains "Which dose is safe?", as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.

Medical Subject Headings (MeSH)
AnimalsBlood VesselsCaffeineCardiovascular DiseasesClinical Studies as TopicCoffeeDisease Models, AnimalDose-Response Relationship, DrugHeartHumansMeta-Analysis as TopicMetabolic Syndrome
Study Links
Quality Scores
Safety50
Efficacy60/10
Quality70/10
Citation Metrics
Total Citations57
Citations/Year6.3
Relative Citation Ratio3.06
NIH Percentile85.4%
Research Impact Scores
APT Score0.95
Weight Score0.93
Normalized Score0.58
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