Effects of Nutritional Supplements on Muscle Mass and Activities of Daily Living in Elderly Rehabilitation Patients with Decreased Muscle Mass: A Randomized Controlled Trial.
Study Goal
To investigate whether combining nutritional supplementation with resistance training improves skeletal muscle mass and activities of daily living in elderly patients with disabilities during convalescent rehabilitation.
Results Summary
The study found that resistance training combined with nutritional supplementation significantly improved calf circumference, arm circumference, Barthel Index scores, and serum albumin levels compared to resistance training alone. These results suggest that nutritional intervention enhances the benefits of resistance training for muscle mass and daily functioning in elderly rehabilitation patients.
Population
Elderly inpatients with decreased skeletal muscle mass in a convalescent rehabilitation unit.
Effective Dosage
Not specified
Duration
2-6 months (from admission to discharge)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
resistance training plus nutritional supplementation | increase | calf circumference | elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit | 3.2 (95%CI: 2.0-4.4) | Significant treatment effects were seen | #1 |
resistance training plus nutritional supplementation | increase | arm circumference | elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit | 1.4 (95%CI: 0.8-2.1) | Significant treatment effects were seen | #2 |
resistance training plus nutritional supplementation | increase | Barthel Index score | elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit | 11.2 (95%CI: 0.5-21.8) | Significant treatment effects were seen | #3 |
resistance training plus nutritional supplementation | increase | serum albumin level | elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit | 0.3 (95%CI: 0.1-0.5) | Significant treatment effects were seen | #4 |
nutritional intervention added to resistance training | increase | skeletal muscle mass | elderly patients with disabilities in a convalescent rehabilitation setting | - | may improve | #5 |
nutritional intervention added to resistance training | increase | activities of daily living | elderly patients with disabilities in a convalescent rehabilitation setting | - | may improve | #6 |
OBJECTIVE: To investigate the effects of nutritional intervention with resistance training on skeletal muscle mass in elderly patients with disabilities in a convalescent rehabilitation setting. DESIGN: A randomized controlled trial. (UMIN Clinical Trials Registry ID: UMIN000006238). SETTING: A rehabilitation hospital. PARTICIPANTS: 39 elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit. INTERVENTIONS: A combination of resistance training plus nutritional supplementation (R/N group) or resistance training alone (R group). The training and supplementation were conducted essentially from the patient's admission to discharge (2-6 months). OUTCOME MEASURES: The patients were evaluated at the time of admission and at the end of the intervention for skeletal muscle mass (calf circumference [CC] as a primary outcome, and arm circumference [AC]), hand grip strength (HG), Mini-Nutritional Assessment-Short Form (MNA®-SF) score, serum albumin level (Alb), body mass index (BMI), and activities of daily living (ADL) as represented by the Barthel Index (BI) score. RESULTS: Significant treatment effects were seen for CC, AC, BI, Alb in the R/N group compared to the R group. A mean treatment effect of 3.2 (95%CI: 2.0-4.4) was seen in CC, 1.4 (95%CI: 0.8-2.1) was seen in AC, 11.2 (95%CI: 0.5-21.8) was seen in BI, 0.3 (95%CI: 0.1-0.5) was seen in Alb. CONCLUSION: The results of this study suggest that nutritional intervention added to resistance training during convalescent rehabilitation may improve skeletal muscle mass and activities of daily living.