Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents.
Study Goal
The researchers aimed to evaluate the potential protective effects of flavonoids against breast cancer and their role in altering cancer-related signaling pathways.
Results Summary
The study found that flavonoids exhibit anti-inflammatory, anti-oxidant, and anti-cancer properties, with epidemiologic evidence linking flavonoid-rich diets to reduced breast cancer risk. However, no natural flavonoid has been approved for breast cancer treatment, though they serve as lead compounds for synthetic agents.
Population
Not specified (general population inferred from epidemiologic studies).
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
flavonoids | neutral | anti-inflammatory, anti-oxidant and anti-cancer properties | - | - | possess | #1 |
an enrich flavonoids diet | decrease | breast cancer | - | - | is linked to a decreased risk | #2 |
flavonoids | neutral | numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation | - | - | alteration | #3 |
supplementation of some flavonoids | neutral | disease prevention | human clinical trials | - | examining the effect | #4 |
natural flavonoids | neutral | synthesis of cancer chemopreventive and/or therapeutic agents | - | - | served as lead compounds | #5 |
Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.