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Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial.

Gastroenterology
November 1, 2015
Lena Böhn et al. (7 authors)
Journal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to compare the effectiveness of a low-FODMAP diet (which includes avoiding gas-producing foods like beans) versus traditional IBS dietary advice in reducing IBS symptoms.

Results Summary

Both diets (low-FODMAP and traditional IBS advice, which included avoiding beans) reduced IBS symptoms similarly, with no significant difference between the groups. Approximately 50% of patients in each group experienced a ≥50% reduction in symptom severity.

Population

75 patients with IBS (Rome III criteria) from gastroenterology outpatient clinics in Sweden.

Effective Dosage

Not specified (dietary avoidance of beans as part of traditional IBS advice).

Duration

4 weeks

Interactions

None mentioned

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
a diet low in FODMAPs
decrease
IBS symptoms
patients with IBS
-
reduces
#1
traditional IBS dietary advice
decrease
IBS symptoms
patients with IBS
-
reduces
#2
a diet low in FODMAPs
decrease
The severity of IBS symptoms
patients who met Rome III criteria for IBS
-
reduced
#3
traditional IBS diet
decrease
The severity of IBS symptoms
patients who met Rome III criteria for IBS
-
reduced
#4
a diet low in FODMAPs
decrease
IBS severity scores
patients in the low-FODMAP group
≥50
had reductions in IBS severity scores ≥50 compared with baseline
#5
traditional IBS diet
decrease
IBS severity scores
patients in the traditional IBS diet group
≥50
had reductions in IBS severity scores ≥50 compared with baseline
#6
Abstract

BACKGROUND & AIMS: A diet with reduced content of fermentable short-chain carbohydrates (fermentable oligo-, di-, monosaccharides, and polyols [FODMAPs]) has been reported to be effective in the treatment of patients with irritable bowel syndrome (IBS). However, there is no evidence of its superiority to traditional dietary advice for these patients. We compared the effects of a diet low in FODMAPs with traditional dietary advice in a randomized controlled trial of patients with IBS. METHODS: We performed a multi-center, parallel, single-blind study of 75 patients who met Rome III criteria for IBS and were enrolled at gastroenterology outpatient clinics in Sweden. Subjects were randomly assigned to groups that ate specific diets for 4 weeks-a diet low in FODMAPs (n = 38) or a diet frequently recommended for patients with IBS (ie, a regular meal pattern; avoidance of large meals; and reduced intake of fat, insoluble fibers, caffeine, and gas-producing foods, such as beans, cabbage, and onions), with greater emphasis on how and when to eat rather than on what foods to ingest (n = 37). Symptom severity was assessed using the IBS Symptom Severity Scale, and patients completed a 4-day food diary before and at the end of the intervention. RESULTS: A total of 67 patients completed the dietary intervention (33 completed the diet low in FODMAPs, 34 completed the traditional IBS diet). The severity of IBS symptoms was reduced in both groups during the intervention (P < .0001 in both groups before vs at the end of the 4-week diet), without a significant difference between the groups (P = .62). At the end of the 4-week diet period, 19 patients (50%) in the low-FODMAP group had reductions in IBS severity scores ≥50 compared with baseline vs 17 patients (46%) in the traditional IBS diet group (P = .72). Food diaries demonstrated good adherence to the dietary advice. CONCLUSIONS: A diet low in FODMAPs reduces IBS symptoms as well as traditional IBS dietary advice. Combining elements from these 2 strategies might further reduce symptoms of IBS. ClinicalTrials.gov ID NCT02107625.

Medical Subject Headings (MeSH)
AdultAgedDietDietary FiberDisaccharidesFemaleFermentationHumansIrritable Bowel SyndromeMaleMiddle AgedMonosaccharidesOligosaccharidesOutpatientsPolymersSeverity of Illness IndexSingle-Blind MethodTreatment OutcomeYoung Adult
Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality85/10
Citation Metrics
Total Citations407
Citations/Year40.7
Relative Citation Ratio18.23
NIH Percentile99.3%
Research Impact Scores
APT Score0.95
Weight Score2.22
Normalized Score0.57
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