Celiac disease, non-celiac gluten sensitivity and inflammatory bowel disease.
Study Goal
The researchers aimed to investigate the association between gluten-related conditions (celiac disease and non-celiac gluten sensitivity) and inflammatory bowel disease, and the potential benefits of a gluten-free diet in these patients.
Results Summary
The study found that IBD prevalence is higher in celiac patients, and Crohn's disease patients with non-celiac gluten sensitivity reported more joint pain, fatigue, and headaches compared to ulcerative colitis patients. A gluten-free diet may be more beneficial for Crohn's disease than ulcerative colitis.
Population
Patients with celiac disease, Crohn's disease, ulcerative colitis, and non-celiac gluten sensitivity.
Effective Dosage
Not Assessed
Duration
Not Assessed
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
iron supplementation | no change | long-term iron deficiency anemia | IBD patients | - | not responsive | #1 |
gluten-containing food | increase | intestinal and extra intestinal symptoms | subject without CD and/or wheat allergy | - | due to the ingestion | #2 |
- | increase | joint pains | Patients with Crohn's disease and SR-NCGS | 50% | more significantly affected | #3 |
- | increase | joint pains | UC patients | 11.1% | more significantly affected | #4 |
- | increase | fatigue | Crohn's patients | 50% | higher percentage | #5 |
- | increase | fatigue | - | 38.9% | higher percentage | #6 |
- | increase | headache | Crohn's patients | 27.3% | higher percentage | #7 |
- | increase | headache | - | 22.2% | higher percentage | #8 |
gluten free diet | increase | - | CrD | - | may be useful more | #9 |
gluten free diet | increase | - | UC | - | may be useful more | #10 |
Celiac disease (CD) and inflammatory bowel disease (IBD), such as Crohn's disease (CrD) and ulcerative colitis (UC), are chronic inflammatory condition of the gastro-intestinal tract. The prevalence of IBD in celiac patients has been reported as 5-10 times higher than in the general population. The possibility of the presence of CD in IBD should be considered in IBD patients with long-term iron deficiency anemia (IDA) not responsive to iron supplementation. Non-celiac gluten sensitivity (NCGS) is characterized by intestinal and extra intestinal symptoms due to the ingestion of gluten-containing food in subject without CD and/or wheat allergy. Patients with Crohn's disease and SR-NCGS were more significantly affected by joint pains compared to UC patients (50% versus 11.1%). In Crohn's patients, a higher percentage of fatigue (50% versus 38.9%) and headache (27.3% versus 22.2%) was evident. For the association between NCGS and IBD new studies are warranted and, at this moment, a gluten free diet (GFD) may be useful more in CrD than in UC.