Parkinson's disease and intensive exercise therapy--a systematic review and meta-analysis of randomized controlled trials.
Study Goal
To evaluate and compare the effects of intensive exercise therapy modalities (Resistance Training, Endurance Training, and Other Intensive Training Modalities) on Parkinson's Disease.
Results Summary
Intensive exercise therapy (including walking) is feasible and safe in Parkinson's Disease, with strong evidence that Resistance Training improves muscle strength and moderate evidence that Endurance Training improves cardio-respiratory fitness. Walking performance may benefit, but findings are inconsistent.
Population
Individuals with Parkinson's Disease.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Resistance Training (RT) | increase | muscle strength | Parkinson's Disease (PD) | g'=0.54 [95%CI 0.22;0.86] | can improve | #1 |
Endurance Training (ET) | increase | cardio-respiratory fitness | Parkinson's Disease (PD) | - | can improve | #2 |
Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) | increase | balance | Parkinson's Disease (PD) | - | may have beneficial effects on | #3 |
Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) | increase | walking performance | Parkinson's Disease (PD) | - | may have beneficial effects on | #4 |
Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) | decrease | Unified Parkinson's Disease Rating Scale-III (UPDRS-III) score | Parkinson's Disease (PD) | - | may have beneficial effects on | #5 |
Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) | increase | quality of life | Parkinson's Disease (PD) | - | may have beneficial effects on | #6 |
intensive exercise therapy (RT, ET and OITM) | no change | - | Parkinson's Disease (PD) | - | is feasible and safe | #7 |
exercise therapy | no change | any outcomes | - | - | No studies find deterioration in any outcomes following | #8 |
OBJECTIVE: To evaluate and compare the effect of 3 intensive exercise therapy modalities - Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) - in Parkinson's Disease (PD). Design A systematic review and meta-analysis of randomized controlled trials. METHODS: A systematic literature search was conducted (Embase, Pubmed, Cinahl, SPORTDiscus, Cochrane, PEDro), which identified 15 studies that were categorized as RT, ET or OITM. The different exercise modalities were reviewed and a meta-analysis evaluating the effect of RT on muscle strength was made. RESULTS: In PD intensive exercise therapy (RT, ET and OITM) is feasible and safe. There is strong evidence that RT can improve muscle strength in PD, which is underlined by the meta-analysis (g'=0.54 [95%CI 0.22;0.86]). There is moderate evidence that ET can improve cardio-respiratory fitness in PD. RT, ET and OITM may have beneficial effects on balance, walking performance, Unified Parkinson's Disease Rating Scale-III (UPDRS-III) score and quality of life in PD, but findings are inconsistent. No studies find deterioration in any outcomes following exercise therapy. CONCLUSION: RT, ET and OITM all represent feasible, safe and beneficial adjunct rehabilitation therapies in PD.