Muscular and functional effects of partitioning exercising muscle mass in patients with chronic obstructive pulmonary disease - a study protocol for a randomized controlled trial.
Study Goal
The researchers aimed to compare the effects of single-limb versus two-limb high-repetitive resistance training on functional exercise capacity and muscle function in patients with COPD and to investigate underlying mechanisms.
Results Summary
The study did not report specific results in the abstract, but it focused on measuring changes in 6-minute walking distance, muscle strength, endurance, and other physiological markers after 8 weeks of training. The abstract indicates the study will provide insights into the comparative efficacy and mechanisms of these training modalities.
Population
Patients with stable severe to very severe COPD aged over 40 and healthy controls.
Effective Dosage
Three times/week for 8 weeks (using elastic bands).
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
single-limb, high-repetitive, resistance training with elastic bands, three times/week for 8 weeks | increase | limb muscle function and functional exercise capacity | patients with chronic obstructive pulmonary disease (COPD) | - | may increase | #1 |
single-limb, high-repetitive, resistance training with elastic bands, three times/week for 8 weeks | decrease | limiting exertional symptoms | patients with chronic obstructive pulmonary disease (COPD) | - | minimizing the occurrence of | #2 |
single-limb, high-repetitive, resistance training with elastic bands, three times/week for 8 weeks | neutral | 6-min walking distance | patients with stable severe to very severe COPD who are older than 40 years of age | - | change in | #3 |
two-limb high-repetitive resistance training with elastic bands, three times/week for 8 weeks | neutral | 6-min walking distance | patients with stable severe to very severe COPD who are older than 40 years of age | - | change in | #4 |
single-limb, high-repetitive, resistance training with elastic bands, three times/week for 8 weeks | neutral | limb muscle strength and endurance capacity, key protein involved in quadriceps anabolic/catabolic signalization, fiber-type distribution and capillarization, subjective dyspnea and muscle fatigue, muscle oxygenation, cardiorespiratory demand and health-related quality-of-life | patients with stable severe to very severe COPD who are older than 40 years of age | - | changes in | #5 |
two-limb high-repetitive resistance training with elastic bands, three times/week for 8 weeks | neutral | limb muscle strength and endurance capacity, key protein involved in quadriceps anabolic/catabolic signalization, fiber-type distribution and capillarization, subjective dyspnea and muscle fatigue, muscle oxygenation, cardiorespiratory demand and health-related quality-of-life | patients with stable severe to very severe COPD who are older than 40 years of age | - | changes in | #6 |
single-limb high-repetitive resistance training | neutral | contractile fatigue, exercise stimulus (the product of number of repetition and load), subjective dyspnea and muscle fatigue, muscle oxygenation, and cardiorespiratory demand during upper and lower limb exercises | patients with COPD and healthy controls | - | acute effects of | #7 |
two-limb high-repetitive resistance training | neutral | contractile fatigue, exercise stimulus (the product of number of repetition and load), subjective dyspnea and muscle fatigue, muscle oxygenation, and cardiorespiratory demand during upper and lower limb exercises | patients with COPD and healthy controls | - | acute effects of | #8 |
BACKGROUND: Low-load, high-repetitive single-limb resistance training may increase limb muscle function and functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD) while minimizing the occurrence of limiting exertional symptoms. Whether high-repetitive single-limb resistance training would perform better than high-repetitive two-limb resistance training is unknown. In addition, the mechanisms underlying possible benefits of high-repetitive resistance training has not been investigated. The aims of this study are to compare single versus two-limb high-repetitive resistance training in patients with COPD and to investigate mechanisms of action of these training modalities. METHODS/DESIGN: This trial is a prospective, assessor-blind, randomized controlled trial. The participants are patients with stable severe to very severe COPD who are older than 40 years of age and healthy controls. The intervention is single-limb, high-repetitive, resistance training with elastic bands, three times/week for 8 weeks. The control is two-limb high-repetitive resistance training with elastic bands, three times/week for 8 weeks. The primary outcomes is change in the 6-min walking distance after 8 weeks of single-limb or two-limb high-repetitive resistance training. The secondary outcomes are changes in limb muscle strength and endurance capacity, key protein involved in quadriceps anabolic/catabolic signalization, fiber-type distribution and capillarization, subjective dyspnea and muscle fatigue, muscle oxygenation, cardiorespiratory demand and health-related quality-of-life after 8 weeks of single-limb or two-limb high-repetitive resistance training. The acute effects of single-limb versus two-limb high-repetitive resistance training on contractile fatigue, exercise stimulus (the product of number of repetition and load), subjective dyspnea and muscle fatigue, muscle oxygenation, and cardiorespiratory demand during upper and lower limb exercises will also be investigated in patients with COPD and healthy controls. Randomization will be performed using a random number generator by a person independent of the recruitment process, using 1:1 allocation to the intervention and the control group using random block sizes. BLINDING: All outcome assessors will be blinded to group assignment. DISCUSSION: The results of this project will provide important information to help developing and implementing customized exercise training programs for patients with COPD. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT02283580 Registration date: 4 November 2014. First participant randomized: 10 November 2014.