Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes: a systematic review.
Study Goal
The researchers aimed to evaluate the antidiabetic properties of Astragalus membranaceus and its bioactive compounds (polysaccharides, saponins, flavonoids) in treating diabetes mellitus and its complications.
Results Summary
The study highlights Astragalus's potential antidiabetic effects, particularly its polysaccharides, saponins, and flavonoids, which show promise in addressing type 1 and type 2 diabetes through mechanisms like improving insulin resistance and glucose metabolism. However, specific clinical outcomes are not detailed in the abstract.
Population
Not specified (general diabetes mellitus population, including type 1 and type 2).
Effective Dosage
Not provided
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Astragalus membranaceus | neutral | diabetes mellitus | - | - | rich in anti-diabetic compounds | #1 |
Astragalus membranaceus polysaccharides (APS) | neutral | diabetes mellitus | - | - | anti-diabetic compounds | #2 |
Astragalus membranaceus saponins (ASS) | neutral | diabetes mellitus | - | - | anti-diabetic compounds | #3 |
Astragalus membranaceus flavonoids (ASF) | neutral | diabetes mellitus | - | - | anti-diabetic compounds | #4 |
Astragalus membranaceus | neutral | diabetes mellitus | - | - | various biological activities | #5 |
Astragalus membranaceus | neutral | diabetes mellitus | - | - | antidiabetic properties | #6 |
Astragalus membranaceus total polysaccharides, saponins and flavonoids fractions | neutral | diabetes mellitus | - | - | most studied | #7 |
Astragalus membranaceus several isolated compounds | neutral | diabetes mellitus | - | - | most studied | #8 |
Diabetes mellitus (DM) is a serious chronic metabolic disease which disease afflicting at present now afflicts approximately 4% of world population worldwide. Nowadays, the need for more potent and safe drugs to supply the present anti-diabetic and treated drugs has become an imperative. Astragalus membranaceus, the most common Chinese herb and key-component of many Chinese herbal anti-diabetic formulas, is rich in anti-diabetic compounds: polysaccharides (APS), saponins (ASS), and flavonoids (ASF) etc. Because of its various biological activities, especially its antidiabetic properties, that continuously arouse different studies. Recent studies focused on type 1 and type 2 treatment, respectively caused by autoimmune destruction of pancreatic beta cells and insulin resistance and deficient glucose metabolism. Its total polysaccharides, saponins and flavonoids fractions and several isolated compounds have been the most studied. This paper discusses diabetic treatment and pharmacological action of the biological ingredients in relation to diabetes mellitus and diabetic complications.