Mediterranean diet reduces thromboxane A2 production in atrial fibrillation patients.
Study Goal
The researchers aimed to evaluate the effect of wine, as part of the Mediterranean diet, on platelet activation in patients with atrial fibrillation.
Results Summary
The study found a significant inverse correlation between wine consumption and urinary 11-dehydro-TxB2 levels, suggesting wine may reduce platelet activation. No differences in ischemic or bleeding events were observed across different levels of Mediterranean diet adherence.
Population
801 non-valvular atrial fibrillation patients on chronic warfarin/acenocumarol treatment.
Effective Dosage
Not specified
Duration
Mean follow-up of 33.9 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean diet | decrease | stroke and myocardial infarction | - | - | reduces the incidence | #1 |
Mediterranean diet | decrease | urinary excretion of 11-dehydro-thromboxane (Tx) B2 | patients with atrial fibrillation | Rs: -0.356, p < 0.001 | significant inverse correlation | #2 |
olive oil | decrease | 11-dehydro-TxB2 | patients with atrial fibrillation | β = -0.130, p = 0.007 | independently associated | #3 |
wine | decrease | 11-dehydro-TxB2 | patients with atrial fibrillation | β = -0.102, p = 0.036 | independently associated | #4 |
antiplatelet drugs | decrease | 11-dehydro-TxB2 | patients with atrial fibrillation | β = -0.098, p = 0.045 | independently associated | #5 |
Mediterranean diet | no change | ischemic or bleeding events | patients with atrial fibrillation | - | no differences in the rate | #6 |
BACKGROUND & AIMS: Platelet activation plays a major role in cardiovascular events (CVEs). Mediterranean diet (Med-Diet) reduces the incidence of stroke and myocardial infarction but it is still unclear if it affects platelet activation. Aim of the study was to evaluate the effect of Med-Diet on the urinary excretion of 11-dehydro-thromboxane (Tx) B2, a marker of in vivo platelet activation, in patients with atrial fibrillation (AF). METHODS: Prospective observational cohort study including 801 non-valvular AF patients on chronic treatment with warfarin/acenocumarol referring to I Medical Clinic - Atherothrombosis Center of Sapienza University of Rome, Italy, from February 2008 to December 2013. Adherence to Med-Diet was evaluated by a short nine-items dietary questionnaire. Urinary excretion of 11-dehydro-TxB2 was measured in all patients. RESULTS: Mean follow-up was 33.9 (±19.8) months, yielding 2223 patient/year of observation. Mean age of patients was 73.3 (±8.9) years, 43.7% were female. Median value of urinary TxB2 was 105.5 [60.0-190.0] ng/mg creatinine. We found a significant inverse correlation between total Med-Diet score and 11-dehydro-TxB2 values (Rs: -0.356, p < 0.001). In a multivariable stepwise linear regression analysis, history of stroke/TIA (β = 0.146, p = 0.003), olive oil (β = -0.130, p = 0.007), wine (β = -0.102, p = 0.036) and antiplatelet drugs (β = -0.098, p = 0.045) were independently associated to 11-dehydro-TxB2. We found no differences in the rate of ischemic or bleeding events across tertiles of Med-Diet score during follow-up. CONCLUSIONS: Med-Diet adherence is inversely associated to urinary excretion of 11-dehydro-TxB2, suggesting that Med-Diet may favorably affect platelet function in AF patients. Clinical Trial Registration: ClinicalTrials.gov NCT01882114.