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Translation of research into clinical practice: a case study of calcium supplement prescribing in New Zealand.

The New Zealand medical journal
January 1, 1970
Mark J Bolland et al. (3 authors)
Journal ArticleMeta-AnalysisResearch Support, Non-U.S. Gov'tReviewHuman Study
Extracted Claims (8)
InterventionDirectionEndpointPopulationDosageImpactClaim #
calcium supplements
increase
cardiovascular risk
-
-
increase
#1
calcium supplements
increase
prescriptions
New Zealand
-
increased rapidly
#2
calcium supplements
no change
prescriptions
New Zealand
-
plateaued
#3
calcium supplements
decrease
prescriptions
New Zealand
-
rapidly declined
#4
calcium supplements
decrease
monthly prescriptions
New Zealand
66%
decreased
#5
calcium carbonate
increase
annual cost
-
from $1.2 to $2.4 million
increased
#6
calcium carbonate
decrease
annual cost
-
by $1.5 million
decreased
#7
calcium carbonate
decrease
cumulative cost
-
$3.9 million
reduction
#8
Abstract

AIMS: Researchers are commonly requested to describe potential benefits of their research for New Zealand in funding applications, but such benefits can be difficult to precisely determine. Recently, we reported that calcium supplements increase cardiovascular risk. We investigated the impact of this research on prescriptions of calcium supplements in New Zealand. METHODS: Data on the number of calcium supplement prescriptions in New Zealand from 2000-2012 were obtained from the Ministry of Health and the total costs of calcium carbonate from PHARMAC. RESULTS: Calcium prescriptions increased rapidly between 2000 and 2007, plateaued after the publication of a randomised controlled trial in 2008, and then rapidly declined after publication of a meta-analysis in 2010. Since 2007, monthly prescriptions have decreased by 66%. From 2000 to 2006, the annual cost of calcium carbonate increased from $1.2 to $2.4 million, but from 2007 to 2012, the annual cost decreased by $1.5 million, with a cumulative reduction in cost of $3.9 million. There were substantial regional variations in declines in prescription numbers, and in 2012 prescribing rates. CONCLUSION: Public-good funding of independent researchers to conduct randomised clinical trials with meaningful clinical outcomes and meta-analyses of such trials can translate into substantial benefits through cost savings.

Medical Subject Headings (MeSH)
CalciumCardiovascular DiseasesDietary SupplementsEpidemiologic MethodsHumansNew ZealandObservationPrescriptionsRandomized Controlled Trials as TopicResearch Design
Study Links
PubMed ID25225760
Citation Metrics
Total Citations3
Citations/Year0.3
Relative Citation Ratio0.11
NIH Percentile5.4%
Research Impact Scores
APT Score0.25
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