Polyphenols-rich natural products for treatment of diabetes.
Study Goal
The researchers aimed to evaluate the potential of polyphenol-rich foods like coffee in modulating carbohydrate metabolism and improving insulin response in type 2 diabetes.
Results Summary
The study suggests that coffee, as a polyphenol-rich beverage, may help decrease insulin resistance, improve glucose utilization, and offer a natural alternative for diabetes management. However, specific results for coffee alone were not detailed.
Population
Diabetic patients (type 2 diabetes mellitus) and animal models.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
polyphenols-rich natural products | neutral | type 2 diabetes mellitus | - | - | may offer unique treatment modalities | #1 |
Natural products | neutral | carbohydrate metabolism | - | - | modulate | #2 |
Natural products | increase | beta-cells integrity and physiology | - | - | restoring | #3 |
Natural products | increase | insulin releasing activity | - | - | enhancing | #4 |
Natural products | increase | glucose using | - | - | enhancing | #5 |
Sea buckthorn berries, red grapes, bilberries, chokeberries, cocoa, coffee, green tea | decrease | insulin response | - | - | may decrease | #6 |
polyphenols | neutral | carbohydrate and lipid metabolism | Animal and human studies | - | modulate | #7 |
polyphenols | decrease | glycemia | Animal and human studies | - | decrease | #8 |
polyphenols | decrease | insulin resistance | Animal and human studies | - | decrease | #9 |
polyphenols | increase | lipid metabolism | Animal and human studies | - | increase | #10 |
polyphenols | decrease | oxidative stress | Animal and human studies | - | optimize | #11 |
polyphenols | decrease | inflammatory processes | Animal and human studies | - | optimize | #12 |
Currently, experimental and clinical evidences showed that polyphenols-rich natural products, like nutraceuticals and food supplements, may offer unique treatment modalities in type 2 diabetes mellitus (DM), due to their biological properties. Natural products modulate the carbohydrate metabolism by various mechanisms, such as restoring beta-cells integrity and physiology, enhancing insulin releasing activity, and the glucose using. Sea buckthorn berries, red grapes, bilberries, chokeberries and popular drinks like cocoa, coffee and green tea are all rich in polyphenols and may decrease the insulin response, offer in g a natural alternative of treatment in diabetes. Therefore, researches are now focused on potential efficacies of different types of polyphenols, including flavonoids, phenolic acids, lignans, anthocyans and stilbenes. Animal and human studies showed that polyphenols modulate carbohydrate and lipid metabolism, decrease glycemia and insulin resistance, increase lipid metabolism and optimize oxidative stress and inflammatory processes. It is important to understand the proper dose and duration of supplementation with polyphenols-rich extracts in order to guide effective therapeutic interventions in diabetic patients.