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Nutraceuticals: a novel concept in prevention and treatment of Alzheimer's disease and related disorders.

Journal of Alzheimer's disease : JAD
January 1, 2014
Gonzalo A Farías et al. (4 authors)
Journal ArticlePortraitResearch Support, Non-U.S. Gov'tReviewHuman Study
Study Details

Study Goal

The researchers aimed to review the potential role of antioxidants and other nutraceuticals in modifying neurodegenerative processes and improving cognitive function in Alzheimer's disease.

Results Summary

The abstract suggests that antioxidants and nutraceuticals may have neuroprotective effects and could influence the prevention or treatment of Alzheimer's disease, but it does not provide specific efficacy data.

Population

Individuals with or at risk of Alzheimer's disease and related disorders.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (8)
InterventionDirectionEndpointPopulationDosageImpactClaim #
diet modifications
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#1
lipid consumption
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#2
carbohydrates consumption
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#3
vitamin supplementation
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#4
antioxidant compounds with neuroprotective activity
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#5
nutraceutical compounds with neuroprotective activity
neutral
prevention and treatment of Alzheimer's disease and related disorders
-
-
possible effects
#6
nutraceuticals and nutritional bioactive compounds
neutral
physiopathological processes responsible for neurodegeneration
-
-
may be able to modify
#7
nutraceuticals and nutritional bioactive compounds
neutral
pro-cognitive properties
-
-
may be able to have
#8
Abstract

Alzheimer's disease is a growing health problem worldwide. The pharmaceutical industry has not recently developed any new drugs that have had a significant impact on the natural history of the disease, so considerable attention has been given to nutraceuticals and nutritional bioactive compounds that can be obtained directly from diet or supplementation. These compounds may be able to modify physiopathological processes responsible for neurodegeneration and/or to have pro-cognitive properties. Here, we review current knowledge on the role of diet modifications, lipid and carbohydrates consumption, vitamin supplementation, and the possible effects of antioxidant and nutraceutical compounds with neuroprotective activity, in the prevention and treatment of Alzheimer's disease and related disorders.

Medical Subject Headings (MeSH)
Alzheimer DiseaseDietary SupplementsHumans
Study Links
Quality Scores
SafetyNot Assessed
Efficacy65/10
Quality70/10
Citation Metrics
Total Citations31
Citations/Year2.8
Relative Citation Ratio1.25
NIH Percentile58.6%
Research Impact Scores
APT Score0.50
Weight Score1.55
Normalized Score0.60
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