The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis.
Study Goal
The researchers aimed to determine the effect of mushroom beta-glucans (MBGS) on tumor inhibition and metastasis in Lewis lung carcinoma (LLC) bearing mice when combined with radiation therapy.
Results Summary
MBGS, when used with radiation therapy, effectively controlled tumor growth and metastasis in LLC-bearing mice. It also showed potential protective effects against wounds and hair loss caused by tumor overgrowth.
Population
C57BL/6 mice with Lewis lung carcinoma (LLC).
Effective Dosage
Not available
Duration
Not available
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum | increase | NK cell-mediated cytotoxicity | mice without LLC bearing | - | enhances | #1 |
MBGS in conjunction with radiation therapy | decrease | tumor growth | LLC bearing mice (C57BL/6) | - | were effective in controlling | #2 |
MBGS in conjunction with radiation therapy | decrease | rate of metastasis | LLC bearing mice (C57BL/6) | - | were effective in controlling | #3 |
MBGS | decrease | wounds | LLC bearing mice | - | can potentially serve as a protective factor for | #4 |
MBGS | decrease | hair loss | LLC bearing mice | - | can potentially serve as a protective factor for | #5 |
This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhibition by examining size of the primary tumor and rate of metastasis in Lewis lung carcinoma (LLC) bearing mice (C57BL/6), given oral administration of MBGS with radiation therapy. A previous result showed that MBGS enhances NK cell-mediated cytotoxicity in mice without LLC bearing in advance. Furthermore, applications of MBGS in conjunction with radiation therapy were effective in controlling tumor growth, and rate of metastasis, life threatening, and can potentially serve as a protective factor for wounds and hair loss that resulted from the overgrowth of primary tumor in LLC bearing mice.