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Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males.

European journal of applied physiology
June 1, 2014
Matthew B Cooke et al. (10 authors)
Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to determine whether post-exercise creatine monohydrate (CrM) consumption enhances body composition and muscle strength compared to resistance training alone in middle to older males.

Results Summary

The study found no significant supplement interaction effects, indicating CrM did not enhance body composition or muscle strength beyond resistance training alone. Significant improvements were observed in muscle strength and body composition over time, but these were attributed to resistance training rather than CrM supplementation.

Population

Middle to older males aged 55–70 years.

Effective Dosage

Initial loading phase: 20 g/day CrM + 5 g/day CHO for 7 days; maintenance: ~8.8 g CrM + 5 g CHO on training days.

Duration

12 weeks.

Interactions

None mentioned.

Extracted Claims (8)
InterventionDirectionEndpointPopulationDosageImpactClaim #
creatine monohydrate (CrM) consumption post-exercise
no change
body composition
middle to older males
no significant change
does not provide greater enhancement
#1
creatine monohydrate (CrM) consumption post-exercise
no change
muscle strength
middle to older males
no significant change
does not provide greater enhancement
#2
high intensity resistance training program
increase
1RM bench press
middle to older males
-
significant time effect was observed
#3
high intensity resistance training program
increase
leg press
middle to older males
-
significant time effect was observed
#4
high intensity resistance training program
increase
body mass
middle to older males
-
significant time effect was observed
#5
high intensity resistance training program
increase
fat-free mass
middle to older males
-
significant time effect was observed
#6
high intensity resistance training program
increase
total myofibrillar protein
middle to older males
-
significant time effect was observed
#7
12-week resistance training
increase
type II fibers
middle to older males
-
trend for larger muscle fiber cross-sectional area
#8
Abstract

PURPOSE: The present study evaluated the effects of creatine monohydrate (CrM) consumption post-exercise on body composition and muscle strength in middle to older males following a 12-week resistance training program. METHODS: In a double-blind, randomized trial, 20 males aged between 55 and 70 years were randomly assigned to consume either CrM-carbohydrate (CHO) [20 g days(-1) CrM + 5 g days(-1) CHO × 7 days, then 0.1 g kg(-1) CrM + 5 g CHO on training days (average dosage of ~8.8 g)] or placebo CHO (20 g days(-1) CHO × 7 days, then 5 g CHO on training days) while participating in a high intensity resistance training program [3 sets × 10 repetitions at 75% of 1 repetition maximum (1RM)], 3 days weeks(-1) for 12 weeks. Following the initial 7-day "loading" phase, participants were instructed to ingest their supplement within 60 min post-exercise. Body composition and muscle strength measurements, blood collection and vastus lateralis muscle biopsy were completed at 0, 4, 8 and 12 weeks of the supplement and resistance training program. RESULTS: A significant time effect was observed for 1RM bench press (p = 0.016), leg press (p = 0.012), body mass (p = 0.03), fat-free mass (p = 0.005) and total myofibrillar protein (p = 0.005). A trend for larger muscle fiber cross-sectional area in the type II fibers compared to type I fibers was observed following the 12-week resistance training (p = 0.08). No supplement interaction effects were observed. CONCLUSION: Post-exercise ingestion of creatine monohydrate does not provide greater enhancement of body composition and muscle strength compared to resistance training alone in middle to older males.

Medical Subject Headings (MeSH)
Adaptation, PhysiologicalAgedCreatineDietary SupplementsDouble-Blind MethodHumansMaleMiddle AgedMuscle StrengthMuscle, SkeletalResistance Training
Study Links
Quality Scores
SafetyNot Assessed
Efficacy30/10
Quality85/10
Citation Metrics
Total Citations23
Citations/Year2.1
Relative Citation Ratio1.17
NIH Percentile55.9%
Research Impact Scores
APT Score0.75
Weight Score1.71
Normalized Score0.49
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