Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats.
Study Goal
The researchers aimed to determine whether Caralluma Fimbriata extract (CFE) could mitigate high-fat diet-induced insulin resistance and oxidative stress in Wistar rats.
Results Summary
CFE administration significantly improved glucose, insulin, leptin, and triglyceride levels while restoring liver antioxidant status in high-fat diet-fed rats. The study did not address long-term human safety or efficacy beyond the 90-day rat model.
Population
Wistar rats fed a high-fat diet (60% fat).
Effective Dosage
200 mg/kg body weight/day.
Duration
90 days.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high-fat diet feeding | increase | hyperglycemia | Wistar rats | - | resulted in the development of | #1 |
high-fat diet feeding | increase | hyperinsulinemia | Wistar rats | - | resulted in the development of | #2 |
high-fat diet feeding | increase | hyperleptinemia | Wistar rats | - | resulted in the development of | #3 |
high-fat diet feeding | increase | hypertriglyceridemia | Wistar rats | - | resulted in the development of | #4 |
high-fat diet feeding | decrease | insulin sensitivity | Wistar rats | - | impaired | #5 |
hydro-alcoholic extract of Caralluma fimbriata (CFE) | decrease | plasma glucose | high-fat diet-fed rats | - | resulted in a significant improvement in | #6 |
hydro-alcoholic extract of Caralluma fimbriata (CFE) | decrease | insulin | high-fat diet-fed rats | - | resulted in a significant improvement in | #7 |
hydro-alcoholic extract of Caralluma fimbriata (CFE) | decrease | leptin | high-fat diet-fed rats | - | resulted in a significant improvement in | #8 |
hydro-alcoholic extract of Caralluma fimbriata (CFE) | decrease | triglycerides | high-fat diet-fed rats | - | resulted in a significant improvement in | #9 |
high-fat diet feeding | increase | lipid peroxidation | high-fat fed rats | - | showed higher levels of | #10 |
high-fat diet feeding | increase | protein oxidation | high-fat fed rats | - | showed higher levels of | #11 |
high-fat diet feeding | decrease | GSH levels | high-fat fed rats | - | showed lower levels of | #12 |
high-fat diet feeding | decrease | enzymatic antioxidants | high-fat fed rats | - | showed lower activities of | #13 |
CFE treatment | no change | all these observed abnormalities | high-fat diet-fed rats | - | prevented | #14 |
The main aim of this study was to investigate the beneficial effects of hydro-alcoholic extract of Caralluma fimbriata (CFE) on the effects of high-fat diet feeding on insulin resistance and oxidative stress in Wistar rats. High-fat diet (60% of fat) and CFE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 90 days. Feeding with high-fat diet resulted in the development of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia and impaired insulin sensitivity (P < 0.05). Administration of CFE to high-fat diet-fed rats for 90 days resulted in a significant improvement in plasma glucose, insulin, leptin, and triglycerides. Regarding liver antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation and lower GSH levels and lower activities of enzymatic antioxidants, while CFE treatment prevented all these observed abnormalities. In conclusion, intake of CFE may be beneficial for the suppression of high-fat diet-induced insulin resistance and oxidative stress.