Vitamin D and gestational diabetes mellitus.
Study Goal
The researchers aimed to determine whether vitamin D supplementation beyond routine prenatal vitamins could prevent gestational diabetes mellitus (GDM) or improve glucose tolerance in women with GDM.
Results Summary
The abstract notes conflicting observational evidence on the association between low vitamin D levels and GDM, with systematic reviews suggesting a higher risk but limited by study diversity and confounding variables. Randomized controlled trial data remain insufficient to confirm efficacy.
Population
Pregnant women, particularly those at risk for or diagnosed with GDM.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D administration | increase | insulin sensitivity and glucose tolerance | - | - | can improve | #1 |
low serum 25-hydroxyvitamin D (25(OH)D) levels | increase | GDM | - | - | are associated with | #2 |
vitamin D deficiency | increase | GDM | - | - | is associated with a higher risk of | #3 |
Gestational diabetes mellitus (GDM) complicates 7 %-14 % of pregnancies in the United States. Vitamin D deficiency also is common in pregnancy. Emerging evidence suggests that Vitamin D administration can improve insulin sensitivity and glucose tolerance, but whether vitamin D supplementation can prevent GDM is unknown. Observational studies provide conflicting evidence as to whether low serum 25-hydroxyvitmain D (25(OH)D) levels are associated with GDM. Two recent systematic reviews concluded that vitamin D deficiency is associated with a higher risk of GDM. However, these reviews are limited by the observational and diverse nature of the included studies. Of greatest concern is the inability to understand how important confounding variables such as race/ethnicity and adiposity might affect the association. Randomized controlled trial data remain limited but are critical to understanding whether supplementation with vitamin D beyond what is contained in routine prenatal vitamins will prevent GDM or improve glucose tolerance for women with GDM.