Severe vitamin D deficiency in a patient with sickle cell disease: a case study with literature review.
Study Goal
The researchers aimed to examine the role of vitamin D in calcium absorption and homeostasis, particularly in sickle cell disease patients with severe vitamin D deficiency.
Results Summary
The study found that sickle cell disease patients are at increased risk of vitamin D deficiency, which may impair calcium absorption, and observed a response to vitamin D supplementation in one case.
Population
Sickle cell disease patients with severe vitamin D deficiency.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | normal absorption of calcium | - | - | is essential for | #1 |
Vitamin D | neutral | calcium homeostasis | - | - | maintain | #2 |
Vitamin D deficiency | neutral | rickets | - | - | results in | #3 |
Vitamin D deficiency | neutral | osteomalacia | - | - | results in | #4 |
Vitamin D deficiency | neutral | bony changes in the spine | - | - | results in | #5 |
- | increase | vitamin D deficiency | Sickle cell disease patients | - | at an increased risk of | #6 |
vitamin D supplementation | neutral | severe vitamin D deficiency | a patient with sickle cell disease | - | response to | #7 |
calcium and vitamin D supplementation | no change | - | sickle cell patients | - | no recommendations for | #8 |
Vitamin D deficiency | neutral | poor absorption | these patients | - | may be due to | #9 |
PURPOSE: Vitamin D is essential for the normal absorption of calcium and to maintain calcium homeostasis. Vitamin D deficiency results in rickets, osteomalacia, and bony changes in the spine. Sickle cell disease patients are at an increased risk of vitamin D deficiency. CASE PRESENTATION: We describe a case of severe vitamin D deficiency and response to vitamin D supplementation in a patient with sickle cell disease. CONCLUSIONS: Currently, there are no recommendations for calcium and vitamin D supplementation in sickle cell patients. Vitamin D deficiency in these patients may be due to poor absorption.