Weight reduction improves markers of hepatic function and insulin resistance in type-2 diabetic patients with non-alcoholic fatty liver.
Study Goal
The researchers aimed to determine the degree of weight reduction needed to improve hepatic function and insulin resistance markers, including Alanine Aminotransferase (ALT), in type-2 diabetics with NAFLD.
Results Summary
The study found a 40.8% reduction in ALT levels in the intervention group, along with improvements in other liver enzymes and insulin resistance markers, following a 15% reduction in BMI through aerobic exercise and diet.
Population
Type-2 diabetic male patients with NAFLD (n=100, divided into two groups).
Effective Dosage
Not specified (intervention involved aerobic exercise and diet regimen).
Duration
Not specified in the abstract.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
aerobic exercise training in addition to diet regimen | decrease | Alkaline Phosphatase (ALP) | type-2 diabetic male patients with NAFLD | 26.99% | reduction | #1 |
aerobic exercise training in addition to diet regimen | decrease | Alanine Aminotransferase (ALT) | type-2 diabetic male patients with NAFLD | 40.8% | reduction | #2 |
aerobic exercise training in addition to diet regimen | decrease | Aspartate Aminotransferase (AST) | type-2 diabetic male patients with NAFLD | 33.81% | reduction | #3 |
aerobic exercise training in addition to diet regimen | decrease | Gamma - Glutamyltransferase (GGT) | type-2 diabetic male patients with NAFLD | 32.73% | reduction | #4 |
aerobic exercise training in addition to diet regimen | decrease | Homeostasis Model Assessment-Insulin Resistance-index (HOMA-IR) | type-2 diabetic male patients with NAFLD | 37.8% | reduction | #5 |
aerobic exercise training in addition to diet regimen | decrease | BMI | type-2 diabetic male patients with NAFLD | 15% | reduction | #6 |
aerobic exercise training in addition to diet regimen | decrease | liver condition and insulin resistance | type-2 diabetics with NAFLD | 15 % reduction in BMI | effective to improve | #7 |
OBJECTIVE: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing dramatically affecting up to 30% of the population worldwide. At present, treatment options are limited and pharmacological management of NAFLD has had disappointing results. Some of the best available evidence to improve NAFLD concerns lifestyle modification. OBJECTIVE: To detect the degree of weight reduction needed to improve the markers of hepatic function and insulin resistance in type-2 diabetics with NAFLD. METHODS: One hundred type-2 diabetic male patients with NAFLD were included into this study and divided into two equal groups. Group (A) received aerobic exercise training in addition to diet regimen. Group (B) received no treatment intervention. RESULTS: There was a 26.99%, 40.8%, 33.81%, 32.73%, 37.8% and 15 % reduction in mean values of Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Gamma - Glutamyltransferase (GGT) and Homeostasis Model Assessment-Insulin Resistance-index (HOMA-IR) and BMI respectively in group (A) at the end of the study. While there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. CONCLUSION: About 15 % reduction in BMI is effective to improve the liver condition and insulin resistance in type-2 diabetics with NAFLD.