Comparison of oxidative stress in pregnancies with and without first trimester iron supplement: a randomized double-blind controlled trial.
Study Goal
The researchers aimed to compare oxidative stress in first-trimester pregnancies with and without iron supplementation.
Results Summary
Iron supplementation was associated with significantly higher oxidative stress (measured by serum γ-glutamyl transferase levels) and increased cases of oligohydramnios compared to placebo and folate groups. Maternal weight gain was also lower in the iron-supplemented group.
Population
108 women in the first trimester of normal pregnancies.
Effective Dosage
Not specified
Duration
Until delivery (follow-up at 14th week of gestation)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
iron supplementation | increase | oxidative stress | - | - | was found to be a cause of | #1 |
iron supplementation | increase | oxidative stress | first trimester pregnancy | - | was found to be associated with an increased | #2 |
iron supplementation | decrease | mean gravidity and parity | group 3 | - | were significantly lower in group with | #3 |
iron supplementation | decrease | maternal weight and weight gain during pregnancy | group 3 | - | were also significantly lower in | #4 |
iron supplementation | increase | serum γ-glutamyl transferase (GGT) levels | group 3 | - | were significantly higher in | #5 |
iron supplementation | increase | cases of oligohydramnios | group 3 | 10 cases | were | #6 |
folate supplementation | increase | cases of oligohydramnios | group 2 | two cases | were | #7 |
placebo | no change | cases of oligohydramnios | group 1 | no cases | were | #8 |
OBJECTIVE: Iron supplementation was found to be a cause of oxidative stress. The aim of this study was to compare oxidative stress in pregnancies with and without iron supplementation in the first trimester pregnancies. METHODS: One hundred and eight women in the first trimester of normal pregnancies were randomly assigned to three groups. Patients were grouped as following: Group 1 received placebo (n = 36), group 2 received folate supplementation (n = 36) and group 3 was directed to the iron supplementation (n = 36). Oxidative stress was assessed at 14th week of gestation by the utilization of serum γ-glutamyl transferase level. Pregnancies were followed until delivery. Relationship between the oxidative stress and pregnancy outcome was assessed among groups. RESULTS: Mean age was similar among groups, mean gravidity and parity were significantly lower in group with Fe supplementation (p < 0.05). Maternal weight and weight gain during pregnancy were also significantly lower in group 3 (p < 0.05). Mean serum albumin levels were similar among groups while serum γ-glutamyl transferase (GGT) levels were significantly higher in group 3. There were 10 cases of oligohydramnios in group 3, two cases in group 2 and no cases in group 1 (p < 0.001). CONCLUSION: Iron supplementation during first trimester pregnancy was found to be associated with an increased oxidative stress.