Effects of supplementation of antioxidant vitamins and lipid peroxidation in critically ill patients.
Study Goal
The researchers aimed to evaluate the effect of antioxidant vitamin supplementation (including Vitamin A) on lipid peroxidation in critically ill patients.
Results Summary
Supplementation with Vitamin A (alongside Vitamins C and E) significantly reduced serum malondialdehyde (MDA) levels, indicating reduced lipid peroxidation, but showed no significant impact on clinical outcomes like mortality or infection incidence.
Population
Critically ill patients (23 on standard diet, 11 on supplemented diet).
Effective Dosage
10,000 IU of Vitamin A daily.
Duration
8 days of intervention, with follow-up until discharge or death.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | decrease | Serum concentrations of MDA | critical patients | - | were significantly lower | #1 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | decrease | Serum concentrations of vitamin E | critical patients | - | were significantly lower | #2 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | increase | vitamin C | critical patients | - | strong tendency to increase | #3 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | no change | mechanical ventilation | critical patients | - | were not significant differences | #4 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | no change | hospitalization days | critical patients | - | were not significant differences | #5 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | no change | mortality | critical patients | - | were not significant differences | #6 |
diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C | no change | infection incidence | critical patients | - | were not significant differences | #7 |
doses of vitamin A, C and E that were indicated | decrease | lipid peroxidation | critical patients | - | were effective for the current lipid peroxidation reduction | #8 |
INTRODUCTION: Critical patients present systemic inflammatory process that can be followed by decrease in plasma concentrations of antioxidant vitamins. OBJECTIVE: [corrected] The aim of this study was to evaluate the effect of the supplementation of antioxidant vitamins in critical patients and their relation with lipid peroxidation. METHODS: 23 patients went on a standard diet (G1) and 11 went on a diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C (G2). The APACHE II score was made. Serum concentrations of retinol, β-carotene, vitamins C and E, malondialdehyde (MDA) and C-reactive protein was measured before (T0) and on the 8th day after the beginning of the nutritional therapy (T1). The groups had been monitored on T0, T1 and T2, (at discharges or death) on the following parameters: mechanical ventilation; hospitalization days; mortality; infection incidence. RESULTS: Serum concentrations of MDA and vitamin E were significantly lower in G2 after intervention and strong tendency to increase vitamin C. There were not significant differences between the groups regarding the clinical parameters. CONCLUSIONS: The doses of vitamin A, C and E that were indicated were effective for the current lipid peroxidation reduction. Introducción: Los pacientes críticos presentan un proceso inflamatorio sistémico que puede seguirse por un descenso en las concentraciones plasmáticas de vitaminas antioxidantes. Objetivo: El objetivo de este estudio fue evaluar el efecto de la suplementación de vitaminas antioxidantes en los pacientes críticos y su relación con la peroxidación lipídica. Métodos: 23 pacientes realizaron una dieta estándar (G1) y 11 una dieta con suplementación diaria de 10.000 UI de vitamina A, 400 mg of vitamina E y 600 mg de vitamina C (G2). Se realizó la puntuación APACHE II. Las concentraciones séricas de retinol, alfa-caroteno, vitaminas C y E, malondialdehído (MDA) y proteína C reactiva se midieron antes (T0) y al octavo día de comenzar con la terapia nutricional (T1). Se monitorizaron los siguientes parámetros en los grupos en T0, T1 y T2, (en el momento del alta o del fallecimiento): ventilación mecánica; días de hospitalización; mortalidad; incidencia de infección. Resultados: Las concentraciones séricas de MDA y vitamina E fueron significativamente menores en el grupo G2 tras la intervención con una fuerte tendencia a aumentar la vitamina C. No hubo diferencias significativas entre los grupos con respecto a los parámetros clínicos. Conclusiones: Las dosis de vitaminas A, C y E que se indicaron fueron eficaces en la reducción actual de la peroxidación lipídica.