Non-celiac gluten sensitivity: clinical relevance and recommendations for future research.
Study Goal
The researchers aimed to review gastrointestinal manifestations of Non-Celiac Gluten Sensitivity (NCGS), discuss evidence for the condition, and explore its pathogenesis.
Results Summary
The abstract highlights increasing interest in NCGS and its benefits from a gluten-free diet, but acknowledges controversy and unclear pathogenesis. It contrasts NCGS with Celiac Disease and wheat allergy, noting the rise in patients without these conditions who benefit from gluten-free diets.
Population
Patients with Non-Celiac Gluten Sensitivity (NCGS), Celiac Disease, and wheat allergy.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free diet | decrease | gastrointestinal symptoms | patients who have neither celiac disease nor wheat allergy | - | derive benefit from | #1 |
BACKGROUND: There has been increasing interest in the entity of Non-Celiac Gluten Sensitivity (NCGS) in recent years; however, it still remains a controversial topic and its pathogenesis is not well understood. Celiac Disease, in contrast, is a well-studied condition that has become increasingly recognized as a prevalent condition arising from a heightened immunological response to gluten. Wheat allergy is an IgE-mediated condition capable of causing a variety of gastrointestinal symptoms. However, the number of patients who have neither celiac disease nor wheat allergy, but appear to derive benefit from a gluten-free diet, is also increasing substantially. The use of the term NCGS as a way of describing this condition has become increasingly prevalent in recent years. PURPOSE: In this review, we will focus on gastrointestinal manifestations of NCGS and discuss the evidence for the condition and its putative pathogenesis. We will discuss areas of controversy and areas for potential future research.