Reduction of facial redness with resveratrol added to topical product containing green tea polyphenols and caffeine.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | decrease | facial redness | Subjects (n=16) presenting with facial redness | - | reduce | #1 |
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | decrease | facial redness in clinical images | Subjects (n=16) presenting with facial redness | 16 of 16 | improvement | #2 |
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | decrease | facial redness in spectrally enhanced images | Subjects (n=16) presenting with facial redness | 13 of 16 | improved | #3 |
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | decrease | facial redness | Subjects (n=16) presenting with facial redness | - | reduction | #4 |
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | decrease | reduction in facial redness | Subjects (n=16) presenting with facial redness | by 6 weeks of treatment | detectable | #5 |
a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine | no change | adverse effects | Subjects (n=16) presenting with facial redness | any subject | not observed | #6 |
The skin product combination of resveratrol, green tea polyphenols, and caffeine | decrease | facial redness | most patients | by 6 weeks of continuous treatment | safely reduces | #7 |
The skin product combination of resveratrol, green tea polyphenols, and caffeine | decrease | facial redness | most patients | with additional treatment | may provide further improvement | #8 |
BACKGROUND/OBJECTIVE: Many topical formulations include antioxidants to improve the antioxidant capability of the skin. This study evaluated the ability of a unique combination of antioxidants including resveratrol, green tea polyphenols, and caffeine to reduce facial redness. METHODS: Subjects (n=16) presenting with facial redness applied the resveratrol-enriched product twice daily to the entire face. Reduction in redness was evaluated by trained staff members and dermatology house staff officers. Evaluators compared clinical photographs and spectrally enhanced images taken before treatment and at 2-week intervals for up to 12 weeks. RESULTS: 16 of 16 clinical images showed improvement and 13 of 16 spectrally enhanced images were improved. Reduction in facial redness continued to evolve over the duration of the study period but was generally detectable by 6 weeks of treatment. Adverse effects were not observed in any subject. CONCLUSION: The skin product combination of resveratrol, green tea polyphenols, and caffeine safely reduces facial redness in most patients by 6 weeks of continuous treatment and may provide further improvement with additional treatment.