Different types of alcoholic beverages and incidence of metabolic syndrome and its components in a Mediterranean cohort.
Study Goal
The researchers aimed to assess the association between alcohol consumption, including wine, and the incidence of Metabolic Syndrome (MS) in a Mediterranean cohort.
Results Summary
The study found no significant association between wine consumption and MS, unlike beer, which showed higher risks for MS and hypertriglyceridemia. Wine did not demonstrate adverse or beneficial effects on MS criteria in this study.
Population
8,103 university graduates (mean age 35.4 years) initially free of MS criteria.
Effective Dosage
≥7 drinks/week (general alcohol consumption; wine-specific dosage not detailed).
Duration
≥6 years of follow-up.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
alcohol consumption (≥7 drinks/wk) | increase | developing Metabolic Syndrome (MS) | University graduates free of any MS criteria | aOR: 1.80; 95% CI: 1.22-2.66; p < 0.001 | presented a significantly higher risk | #1 |
alcohol consumption (≥7 drinks/wk) | increase | hypertriglyceridemia | University graduates free of any MS criteria | aOR: 2.07; 95% CI: 1.46-2.93 | had higher risk | #2 |
alcohol consumption (≥7 drinks/wk) | increase | impaired fasting glucose | University graduates free of any MS criteria | aOR: 1.54; 95% CI: 1.16-2.04 | had higher risk | #3 |
beer consumption (≥7 drinks/wk) | increase | Metabolic Syndrome (MS) | University graduates free of any MS criteria | p for trend = 0.027 | was associated with higher risk | #4 |
beer consumption (≥7 drinks/wk) | increase | hypertriglyceridemia | University graduates free of any MS criteria | aOR: 1.81; 95% CI: 1.02-3.20 | was associated with higher risk | #5 |
beer consumption (≥7 drinks/wk) | decrease | low HDL-cholesterol criterion | University graduates free of any MS criteria | aOR: 0.21; 95% CI: 0.05-0.89 | was associated with lower risk | #6 |
wine consumption | no change | Metabolic Syndrome (MS) | University graduates free of any MS criteria | - | Non-significant association was observed | #7 |
liquor consumption | no change | Metabolic Syndrome (MS) | University graduates free of any MS criteria | - | Non-significant association was observed | #8 |
Consumption of at least seven alcoholic drinks per week | increase | developing Metabolic Syndrome (MS) | subjects initially free of any MS criteria | - | was associated with a higher risk | #9 |
BACKGROUND & AIMS: We prospectively assessed the association between alcohol consumption and the incidence of Metabolic Syndrome (MS) in a Mediterranean cohort. METHODS: We included 8103 (mean age: 35.4 years) University graduates free of any MS criteria and followed-up during ≥6 years. Alcohol consumption was collected with a validated 136-item food frequency questionnaire. New-onset cases of MS were defined according to the updated harmonizing criteria. RESULTS: We observed 341 incident cases of MS. Consumers of ≥7 drinks/wk presented a significantly higher risk of developing MS (aOR: 1.80; 95% CI: 1.22-2.66; p < 0.001) compared with non-drinkers. In addition, alcohol drinkers (≥7 drinks/wk) had higher risk of hypertriglyceridemia (aOR: 2.07; 95% CI: 1.46-2.93) and impaired fasting glucose (aOR: 1.54; 95% CI: 1.16-2.04). Beer consumption was associated with higher risk for MS (p for trend = 0.027) and higher risk of hypertriglyceridemia (aOR: 1.81; 95% CI: 1.02-3.20), but with lower risk of low HDL-cholesterol criterion (aOR: 0.21; 95% CI: 0.05-0.89) for ≥7 drinks/wk versus no consumption. Non-significant association was observed between wine or liquor consumption and MS. CONCLUSIONS: Consumption of at least seven alcoholic drinks per week was associated with a higher risk of developing MS among subjects initially free of any MS criteria.