Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents.
Study Goal
The researchers aimed to compare the response to vitamin D3 supplementation between obese and non-obese Caucasian adolescents, focusing on changes in serum 25-hydroxyvitamin D levels.
Results Summary
Obese adolescents had lower baseline 25(OH)D levels and showed a smaller increase in 25(OH)D levels after vitamin D supplementation compared to non-obese adolescents, indicating a reduced efficacy of supplementation in the obese group.
Population
Obese and non-obese Caucasian adolescents aged 12-18 years.
Effective Dosage
2,000 IU/day of vitamin D3 orally.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) | increase | increment in 25(OH)D levels | obese adolescents | mean change 5.8 vs. 9.8 ng/ml | significantly lower | #1 |
- | increase | mean baseline 25(OH)D level | non-obese subjects | mean 28.9 vs. 25.2 ng/ml | higher | #2 |
Higher doses of vitamin D | neutral | vitamin D deficiency | obese adolescents | - | are required to treat | #3 |
BACKGROUND/AIMS: Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents. METHODS: The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period. RESULTS: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019). CONCLUSIONS: Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.