Comparative evaluation of flavone from Mucuna pruriens and coumarin from Ionidium suffruticosum for hypolipidemic activity in rats fed with high fat diet.
Study Goal
The researchers aimed to compare the hypolipidemic effects of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum in rats fed a high-fat diet.
Results Summary
Flavone from Mucuna pruriens significantly prevented the rise in plasma total and LDL-cholesterol, triglycerides, and phospholipids in high-fat diet-fed rats, though coumarin from Ionidium suffruticosum showed greater cardio-protective effects.
Population
Rats fed a high-fat diet.
Effective Dosage
10 mg/kg body weight per day.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
flavone isolated from Mucuna pruriens | decrease | plasma total and LDL-cholesterol, triglycerides and phospholipids | rats fed with high fat diet | - | significantly prevented the rise | #1 |
coumarin isolated from Ionidium suffruticosum | decrease | plasma total and LDL-cholesterol, triglycerides and phospholipids | rats fed with high fat diet | - | significantly prevented the rise | #2 |
high fat diet | increase | plasma total and LDL-cholesterol, triglycerides and phospholipids | rats | - | showed significant elevation | #3 |
coumarin isolated from Ionidium suffruticosum | decrease | hyperlipidemia | - | - | had showed more cardio protective effect | #4 |
The objective of the study is a comparative evaluation of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum was assessed for the hypolipidemic activity in rats fed with high fat diet. The acute toxicity study was found that flavone (M.pruriens) and coumarin (I.suffruticosum) are safe up to 100 mg/kg, so one tenth of this dose (10 mg/kg) was consider as a evaluation dose. High fat diet group of rats showed significant (p<0.001) elevation in plasma total and LDL-cholesterol, triglycerides and phospholipids. Administration of flavone (M. pruriens) and coumarin isolated from (I.suffruticosum) at the dose of 10mg/kg b.wt/day along with high fat diet significantly (p<0.001) prevented the rise in the plasma total and LDL-cholesterol, triglycerides and phospholipids than that of other extracts. However, treatment of coumarin isolated from (I.suffruticosum) had showed more cardio protective effect against hyperlipidemia than that of flavone (M.pruriens).