Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome.
Study Goal
The researchers aimed to assess the effects of Calcium and vitamin D supplementation on hormonal and metabolic parameters in women with PCOS.
Results Summary
The study found that Calcium and vitamin D supplementation improved androgen levels (reduced total testosterone and androstenedione) and blood pressure in overweight, vitamin D-deficient women with PCOS, but did not significantly affect glucose homeostasis or insulin resistance.
Population
Overweight, vitamin D-deficient women with polycystic ovary syndrome (PCOS) (n=12).
Effective Dosage
530 mg elemental Calcium daily.
Duration
3 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D and Calcium (Ca) supplementation | increase | serum 25OHD | overweight and vitamin D deficient women with PCOS | - | improved | #1 |
vitamin D and Calcium (Ca) supplementation | decrease | total T levels | overweight and vitamin D deficient women with PCOS | - | reductions in | #2 |
vitamin D and Calcium (Ca) supplementation | decrease | androstenedione (A) levels | overweight and vitamin D deficient women with PCOS | - | reductions in | #3 |
vitamin D and Calcium (Ca) supplementation | decrease | BP parameters | participants with baseline BP ≥ 120/80 mmHg | - | significant lowering in | #4 |
vitamin D and Calcium (Ca) supplementation | decrease | BP parameters | those with baseline serum 25OHD ≤20 ng/ml | - | significant lowering in | #5 |
vitamin D and Calcium (Ca) supplementation | no change | parameters of glucose homeostasis | overweight and vitamin D deficient women with PCOS | - | remained unchanged | #6 |
vitamin D and Calcium (Ca) supplementation | no change | insulin resistance (IR) | overweight and vitamin D deficient women with PCOS | - | remained unchanged | #7 |
OBJECTIVE: To assess effects of vitamin D and Calcium (Ca) on hormonal and metabolic milieu of polycystic ovary syndrome (PCOS). DESIGN: Single arm open label trial. METHODS: Twelve overweight and vitamin D deficient women with PCOS underwent a 2 hour oral glucose tolerance testing at baseline and following 3-month supplementation with vitamin D (daily dose of 3533 IU, increased to 8533 IU after the first five participants) and 530 mg elemental Ca daily. MAIN OUTCOME MEASURES: Blood pressure (BP), plasma glucose, insulin, total testosterone (T) androstenedione (A), sex hormone binding globulin, lifestyle parameters were assessed at baseline and following 3-month intervention. Insulin resistance (IR) and area under the curve for glucose and insulin were computed; paired analyses were conducted. RESULTS: Improved serum 25OHD (p < 0.001) and reductions in total T (p = 0.036) and A (p = 0.090) levels were noted following 3-month supplementation, compared to baseline. Significant lowering in BP parameters was seen in participants with baseline BP ≥ 120/80 mmHg (n = 8) and in those with baseline serum 25OHD ≤20 ng/ml (n = 9). Parameters of glucose homeostasis and IR remained unchanged (p > 0.05). CONCLUSIONS: Androgen and BP profiles improved followed three month intervention, suggesting therapeutic implications of vitamin D and Ca in overweight and vitamin D deficient women with PCOS.