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Alternative diets to the classical ketogenic diet--can we be more liberal?

Epilepsy research
July 1, 2012
Maria J Miranda et al. (3 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to summarize the principles and evidence of effectiveness of alternative ketogenic diets (MCT-KD, MAD, LGIT) compared to the classical KD for treating medically refractory epilepsy.

Results Summary

The study found that more liberal versions of the classical KD (MCT-KD, MAD, LGIT) have efficacy close to the classical KD, though no RCT data are available for MAD and LGIT. Factors like age, epilepsy type, lifestyle, and resources are important in diet selection.

Population

Patients with severe medically refractory epilepsy.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
ketogenic diet (KD)
decrease
severe medically refractory epilepsy
-
-
has been used for the treatment of
#1
classical KD
neutral
-
-
-
is restrictive
#2
Medium Chain Triglyceride (MCT)-KD, modified Atkins diet (MAD) and low glycaemic index treatment (LGIT)
no change
efficacy
-
close to
have an efficacy close to
#3
MAD and LGIT
neutral
-
-
-
no RCT data are available for
#4
Abstract

The ketogenic diet (KD), a high-fat, adequate protein, low-carbohydrate diet has been used since 1921 for the treatment of severe medically refractory epilepsy. In the past 15 years, the use of the KD has expanded enormously and a huge amount of clinical evidence of its efficacy is available. The classical KD is however restrictive and therefore alternative more liberal varieties of the classical KD have been developed within the last 8 years. The purpose of this report is to summarise the principles and evidence of effectiveness of the alternative ketogenic diets: Medium Chain Triglyceride (MCT)-KD, modified Atkins diet (MAD) and low glycaemic index treatment (LGIT), compared to the classical KD. The clinical evidence to date suggests that the more liberal versions of the classical KD such as MCT KD, MAD and LGIT have an efficacy close to the classical KD; however, no RCT data are available for MAD and LGIT. This evidence suggests that factors such as age, epilepsy type, lifestyle and resources are important factors in deciding which diet we should start a patient on. This report intends to summarise guidelines based on the evidence available.

Medical Subject Headings (MeSH)
Diet, Carbohydrate-RestrictedDiet, KetogenicEpilepsyGlycemic IndexHumansTreatment OutcomeTriglycerides
Study Links
Quality Scores
SafetyNot Assessed
Efficacy80/10
Quality75/10
Citation Metrics
Total Citations57
Citations/Year4.4
Relative Citation Ratio2.12
NIH Percentile76.3%
Research Impact Scores
APT Score0.75
Weight Score1.48
Normalized Score0.67
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