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Clinical benefits of oral nutritional supplementation for elderly hip fracture patients: a single blind randomised controlled trial.

Age and ageing
January 1, 2013
Ma Wai Wai Myint et al. (9 authors)
Comparative StudyJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to investigate the clinical, nutritional, and rehabilitation effects of oral nutritional supplementation (including calcium and vitamin D) in elderly post-surgical hip fracture patients.

Results Summary

The study found no significant difference in serum albumin levels, functional independence, or mobility scores between groups, but the ONS group showed reduced BMI decline, shorter rehabilitation stays, and fewer infections.

Population

Elderly post-surgical proximal femoral fracture patients in an inpatient rehabilitation setting.

Effective Dosage

Oral calcium and vitamin D supplements (specific dosage not detailed).

Duration

Intervention lasted until hospital discharge, with follow-up at 4 weeks post-discharge.

Interactions

None mentioned

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
oral nutritional supplementation (ONS) in addition to hospital diet
decrease
body mass index (BMI)
elderly post-surgical proximal femoral fracture patients
0.25 and 0.03 kg/m(2) in the ONS group and 0.72 and 0.49 kg/m(2) in the control group at hospital discharge and follow-up, respectively
significant difference in change
#1
oral nutritional supplementation (ONS) in addition to hospital diet
decrease
length of stay in rehabilitation ward
elderly post-surgical proximal femoral fracture patients
3.80 days
shortened
#2
oral nutritional supplementation (ONS) in addition to hospital diet
decrease
total number of infection episodes
elderly post-surgical proximal femoral fracture patients
-
reduced significantly
#3
oral nutritional supplementation (ONS) in addition to hospital diet
no change
serum albumin level
elderly post-surgical proximal femoral fracture patients
-
No difference was observed in the rate of change
#4
oral nutritional supplementation (ONS) in addition to hospital diet
no change
functional independence measure (FIM)
elderly post-surgical proximal femoral fracture patients
-
No difference was observed in the rate of change
#5
oral nutritional supplementation (ONS) in addition to hospital diet
no change
elderly mobility scale (EMS)
elderly post-surgical proximal femoral fracture patients
-
No difference was observed in the rate of change
#6
Abstract

BACKGROUND: malnutrition is an important risk factor for poor outcome in patients recovering after hip fracture surgery. This study aimed to investigate the clinical, nutritional and rehabilitation effects of an oral nutritional supplementation (ONS) in an inpatient rehabilitation setting. METHODS: this was an observer-blinded randomised controlled trial of elderly post-surgical proximal femoral fracture patients. A ready-to-use oral liquid nutritional supplementation (18-24 g protein and 500 kcal per day) in addition to hospital diet was compared with hospital diet only. Both groups received usual rehabilitation therapy and oral calcium and vitamin D supplements. Outcomes were compared at discharge from rehabilitation and after 4 weeks of discharge. The primary outcome parameters were the serum albumin level, the body mass index (BMI), the functional independence measure (FIM) and the elderly mobility scale (EMS). Secondary outcome parameters were frequency of complications, inpatient length of stay, mortality and acute hospital use within 6 months after discharge. RESULTS: a total of 126 patients were recruited, 65 in the supplementation arm and 61 in the control arm. There was a significant difference in change in BMI with a decrease of 0.25 and 0.03 kg/m(2) in the ONS group and 0.72 and 0.49 kg/m(2) in the control group at hospital discharge and follow-up, respectively (P = 0.012). The length of stay in rehabilitation ward was shortened by 3.80 (SE = 1.81, P = 0.04) days favouring the ONS group. The total number of infection episodes was also reduced significantly. No difference was observed in the rate of change of the serum albumin level, the FIM and the EMS. CONCLUSION: clinical and nutritional benefits were seen in this trial but rehabilitation benefits could not be demonstrated.

Medical Subject Headings (MeSH)
Administration, OralAgedAged, 80 and overBody Mass IndexDietary ProteinsDietary SupplementsEnergy IntakeFemaleFollow-Up StudiesHip FracturesHumansInpatientsInsulin-Like Growth Factor ILength of StayMaleSerum AlbuminSingle-Blind Method
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality85/10
Citation Metrics
Total Citations75
Citations/Year6.3
Relative Citation Ratio3.47
NIH Percentile87.8%
Research Impact Scores
APT Score0.95
Weight Score1.74
Normalized Score0.65
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