Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review.
Study Goal
The researchers aimed to determine whether N-Acetylcysteine could effectively modulate oxidative stress markers in experimental models of minimally invasive surgery.
Results Summary
N-Acetylcysteine was found to reduce oxidative stress markers in experimental models, though it did not fully prevent oxidative stress as mesna did. The results were consistent with other agents except pentoxifylline, which showed contrasting effects.
Population
Rats or rabbits subjected to pneumoperitoneum or pneumoretroperitoneum (not full surgical operations).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
erythromycin | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #1 |
melatonin | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #2 |
mesna | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #3 |
verapamil | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #4 |
N-acetylcysteine | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #5 |
zinc | decrease | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | seemed to reduce | #6 |
mesna pretreatment | decrease | oxidative stress | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | prevented | #7 |
mesna pretreatment | no change | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | remained in the sham levels | #8 |
pentoxifylline | no change | oxidative stress markers | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | - | contrasting data were obtained | #9 |
This systematic review aims to synthesize the data on the effectiveness of pharmacological modulation of stress response in minimally invasive surgery. Eligible trials were clinical trials randomized or not or experimental trials that investigated the effect of pharmacological agents on modulation of surgical stress response to minimally invasive surgery. No clinical trials were identified. Eight experimental trials met the inclusion criteria and were obtained in full text. Experimental models were rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum, not to a whole operation. Pharmacological modulation of surgical stress response was attempted with erythromycin, melatonin, mesna, verapamil, pentoxifylline, N-acetylcysteine, and zinc. All the pharmacological agents, except pentoxifylline, seemed to reduce oxidative stress markers. However, only mesna pretreatment prevented oxidative stress, because oxidative stress markers remained in the sham levels. Contrasting data were obtained for pentoxyphilline. In conclusion, available data suggest that pharmacological modulation of surgical stress response to minimally invasive surgery might be feasible.