Association of blood pressure and metabolic syndrome components with magnesium levels in drinking water in some Serbian municipalities.
Study Goal
The researchers aimed to assess the association of magnesium levels in drinking water with blood pressure and metabolic syndrome components in a healthy population.
Results Summary
Higher magnesium levels in drinking water were associated with lower diastolic blood pressure, higher serum magnesium, and lower serum Ca/Mg ratio, suggesting potential benefits for hypertension and metabolic syndrome prevention.
Population
90 healthy blood donors aged 20-50 years from three municipalities in Serbia.
Effective Dosage
Not specified (natural magnesium levels in drinking water: 11 mg/L vs. 42 mg/L).
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water | increase | magnesium deficiency | - | - | increases the risk | #1 |
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water | increase | hypertension | - | - | increases the risk | #2 |
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water | increase | dyslipidemia | - | - | increases the risk | #3 |
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water | increase | type 2 diabetes mellitus | - | - | increases the risk | #4 |
higher mean Mg level in drinking water (42 mg L(-1)) | decrease | Diastolic blood pressure | subjects from Pozarevac | - | was lowest | #5 |
higher mean Mg level in drinking water (42 mg L(-1)) | increase | Serum Mg (sMg) | subjects from Pozarevac | - | was highest | #6 |
higher mean Mg level in drinking water (42 mg L(-1)) | decrease | serum Ca(2+)/Mg (sCa/Mg) | subjects from Pozarevac | - | was lowest | #7 |
total cholesterol levels | neutral | diastolic blood pressure | - | - | were independent predictors | #8 |
sMg levels | neutral | diastolic blood pressure | - | - | were independent predictors | #9 |
sMg levels | neutral | triglycerides | - | - | were independent predictors | #10 |
sCa/Mg | neutral | glucose levels | - | - | predicted | #11 |
Mg supplementation in areas of lower magnesium levels in drinking water | decrease | hypertension | - | - | may be an important measure in the prevention | #12 |
Mg supplementation in areas of lower magnesium levels in drinking water | decrease | MetS | - | - | may be an important measure in the prevention | #13 |
Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of magnesium deficiency and its association with hypertension, dyslipidemia and type 2 diabetes mellitus. The aim of the study was to assess the potential association of mineral contents in drinking water with blood pressure and other components of metabolic syndrome (MetS) (BMI as measure of obesity, triglycerides, glucose, and insulin resistance, index-HOMA IR), in a healthy population. This study was conducted in three randomly selected municipalities (Pozarevac, Grocka and Banovci), and recruited 90 healthy blood donors, aged 20-50 years. The Pozarevac area had a four times higher mean Mg level in drinking water (42 mg L(-1)) than Grocka (11 mg L(-1)). Diastolic blood pressure was lowest in subjects from Pozarevac. Serum Mg (sMg) was highest, and serum Ca(2+)/Mg (sCa/Mg) lowest in subjects from Pozarevac, and after adjustment for confounders (age, gender, BMI), only total cholesterol and sMg levels were independent predictors of diastolic blood pressure, sMg levels were independent predictors of triglycerides, and sCa/Mg predicted glucose levels. These results suggest that Mg supplementation in areas of lower magnesium levels in drinking water may be an important measure in the prevention of hypertension and MetS in general.