Sustained effects of a mindfulness-based stress-reduction intervention in type 2 diabetic patients: design and first results of a randomized controlled trial (the Heidelberger Diabetes and Stress-study).
Study Goal
To determine if mindfulness-based stress reduction (MBSR) reduces psychosocial distress and slows nephropathy progression while improving subjective health status in type 2 diabetes patients.
Results Summary
MBSR reduced depression and improved health status but did not significantly affect albuminuria. Stress reduction was also higher in the intervention group.
Population
Patients with type 2 diabetes and microalbuminuria.
Effective Dosage
Not specified
Duration
5 years (data presented for first year)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
mindfulness-based stress reduction (MBSR) intervention | decrease | depression | patients with type 2 diabetes and microalbuminuria | d = 0.71 | lower levels | #1 |
mindfulness-based stress reduction (MBSR) intervention | increase | health status | patients with type 2 diabetes and microalbuminuria | d = 0.54 | improved | #2 |
mindfulness-based stress reduction (MBSR) intervention | no change | albuminuria | patients with type 2 diabetes and microalbuminuria | no significant differences | No significant differences | #3 |
mindfulness-based stress reduction (MBSR) intervention | decrease | stress | patients with type 2 diabetes and microalbuminuria | d = 0.64 | higher stress reduction | #4 |
mindfulness-based stress reduction (MBSR) intervention | decrease | psychosocial distress | patients with type 2 diabetes | - | prolonged reduction | #5 |
OBJECTIVE: To determine whether a mindfulness-based stress reduction (MBSR) intervention is effective for reducing psychosocial distress (i.e., depression, psychosocial stress) and the progression of nephropathy (i.e., albuminuria) and for improving the subjective health status of patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes and microalbuminuria were randomized to a mindfulness-based intervention (n = 53) or a treatment-as-usual control (n = 57) group. The study is designed to investigate long-term outcomes over a period of 5 years. We present data up to the first year of follow-up (FU). RESULTS: At FU, the MBSR group showed lower levels of depression (d = 0.71) and improved health status (d = 0.54) compared with the control group. No significant differences in albuminuria were found. Per-protocol analysis also showed higher stress reduction in the intervention group (d = 0.64). CONCLUSIONS: MBSR intervention achieved a prolonged reduction in psychosocial distress. The effects on albuminuria will be followed up further.