The role of magnesium in type 2 diabetes: a brief based-clinical review.
Study Goal
The researchers aimed to evaluate the relationship between magnesium intake and the risk of developing type 2 diabetes, based on evidence from epidemiological studies and clinical trials.
Results Summary
Epidemiological studies consistently show an inverse relationship between dietary magnesium intake and type 2 diabetes risk, but clinical trial results on magnesium supplementation's effects on glucose metabolism and insulin sensitivity are scarce and controversial.
Population
General population, with a focus on type 2 diabetes risk.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium | neutral | glucose metabolism | - | - | exerts an essential role | #1 |
magnesium | decrease | risk of developing type 2 diabetes | - | - | could play an important role in the reduction | #2 |
low dietary magnesium intake | increase | risk of developing type 2 diabetes | - | - | is associated with the increased risk | #3 |
magnesium supplementation | neutral | glucose metabolism and insulin sensitivity | - | - | beneficial effects | #4 |
magnesium supplementation | no change | glucose metabolism and insulin sensitivity | - | - | results are controversial | #5 |
dietary magnesium intake | decrease | risk of developing T2D | - | - | shows a strong inverse relationship | #6 |
A growing body of evidence from experimental studies that shows the essential role that magnesium exerts on glucose metabolism has been developed in last years, strongly suggesting that magnesium could plays an important roles in the reduction of the risk of developing type 2 diabetes. In the clinical setting, large epidemiological studies show that low dietary magnesium intake is associated with the increased risk of developing type 2 diabetes; however, results from randomized controlled clinical trials that have evaluated the beneficial effects of magnesium supplementation on glucose metabolism and insulin sensitivity are controversial. In this article we searched (in the electronic databases of Medline, Embase, and the Cochrane Controlled Trials Register up to June 2011) the evidence derived from epidemiological studies and clinical trials, about the relationship between magnesium and type 2 diabetes. The body of evidence from epidemiological studies consistently shows a strong inverse relationship between dietary magnesium intake and the risk of developing T2D; however, results from clinical trials are scarce and controversial.