Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring.
Study Goal
The researchers aimed to determine whether perioperative magnesium sulphate (MgSO₄) supplementation affects the minimal alveolar concentration (MAC) of desflurane and hemodynamic responses during intubation.
Results Summary
The study found that MgSO₄ reduced the MAC of desflurane and suppressed hemodynamic responses (tachycardia and hypertension) during intubation, but prolonged recovery times (extubation, verbal cooperation, and eye opening).
Population
Sixty patients undergoing abdominal surgery under general anesthesia.
Effective Dosage
Not specified in the abstract.
Duration
Perioperative (exact duration not specified).
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
perioperative magnesium sulphate (MgSO(4)) | decrease | MAC values of desflurane | patients undergoing abdominal surgery under general anesthesia | - | was found to be lower | #1 |
perioperative magnesium sulphate (MgSO(4)) | decrease | tachycardia during intubation | patients undergoing abdominal surgery under general anesthesia | - | was found to be lower | #2 |
perioperative magnesium sulphate (MgSO(4)) | decrease | hypertension during intubation | patients undergoing abdominal surgery under general anesthesia | - | was found to be lower | #3 |
infusion of MgSO(4) | increase | time to extubation | patients receiving infusion of MgSO(4) | - | was longer | #4 |
infusion of MgSO(4) | increase | verbal cooperation | patients receiving infusion of MgSO(4) | - | was longer | #5 |
infusion of MgSO(4) | increase | eye opening | patients receiving infusion of MgSO(4) | - | was longer | #6 |
perioperative MgSO(4) infusion | decrease | MAC of desflurane | - | - | decreases | #7 |
perioperative MgSO(4) infusion | decrease | hemodynamic response to intubation | - | - | suppresses | #8 |
BACKGROUND: In this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO(4)) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring. PATIENTS AND METHODS: Sixty patients undergoing abdominal surgery under general anesthesia were randomized into two groups: Mg - receiving perioperative MgSO(4) supplementation and C - control. Anesthesia was titrated to maintain the BIS value between 45-55. RESULTS: MAC values, tachycardia and hypertension during intubation was found to be lower in group Mg compared to group C (p<0.001). Time to extubation, verbal cooperation and eye opening was longer in patients receiving infusion of MgSO(4) (p<0.001). CONCLUSION: We concluded that perioperative MgSO(4) infusion may be used as an adjunct as it decreases MAC of desflurane and suppresses the hemodynamic response to intubation.