Effect of Mediterranean diet on lipid peroxidation marker TBARS in obese patients with OSAHS under CPAP treatment: a randomised trial.
Study Goal
The researchers aimed to compare the effects of the Mediterranean diet and a prudent diet on TBARS levels in obese patients with OSAHS under CPAP treatment.
Results Summary
The prudent diet led to a significant reduction in TBARS levels, similar to the Mediterranean diet, but showed less improvement in weight, BMI, waist circumference, and body fat percentage compared to the Mediterranean diet.
Population
Obese patients with moderate to severe obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment.
Effective Dosage
Not specified
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean diet | decrease | TBARS levels | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | - | decreased notably | #1 |
prudent diet | decrease | TBARS levels | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | - | decreased notably | #2 |
Mediterranean diet | decrease | weight | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -10.8 ± 3.8 | showed a greater reduction | #3 |
Mediterranean diet | decrease | body mass index | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -3.9 ± 1.6 | showed a greater reduction | #4 |
Mediterranean diet | decrease | waist circumference | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -9.9 ± 3.0 | showed a greater reduction | #5 |
Mediterranean diet | decrease | percentage of body fat | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -4.7 ± 2.3 | showed a greater reduction | #6 |
prudent diet | decrease | weight | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -6.9 ± 3.1 | reduction | #7 |
prudent diet | decrease | body mass index | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -2.5 ± 1.0 | reduction | #8 |
prudent diet | decrease | waist circumference | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -5.3 ± 2.6 | reduction | #9 |
prudent diet | decrease | percentage of body fat | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | -2.2 ± 1.5 | reduction | #10 |
Mediterranean diet | no change | TBARS | obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) under continuous positive airway pressure treatment | - | did not reduce more than the prudent diet | #11 |
PURPOSE: The aim of our study was to examine the possible effect of the Mediterranean diet on thiobarbituric acid reacting substances (TBARS) in obese patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) who are under continuous positive airway pressure treatment. METHODS: Nine hundred patients were evaluated during a 1-year period (November 2008-October 2009), and 21 obese patients who met the inclusion criteria, with moderate to severe OSAHS based on overnight attended polysomnography, were included in the study. After randomisation, 11 followed the Mediterranean diet and 10 a prudent diet for a 6-month period. TBARS were measured in serum. RESULTS: TBARS levels decreased notably in both groups (p < 0.05), but no difference was observed between them (p > 0.05). There were significant differences in other characteristics. The Mediterranean diet group showed a greater reduction in weight (-10.8 ± 3.8), body mass index (-3.9 ± 1.6), waist circumference (-9.9 ± 3.0) and percentage of body fat (-4.7 ± 2.3) compared with the other group (-6.9 ± 3.1, -2.5 ± 1.0, -5.3 ± 2.6 and -2.2 ± 1.5, respectively; p < 0.05). CONCLUSIONS: Our results showed that the Mediterranean diet did not reduce the TBARS more than the prudent diet.