The Dietary Approaches to Stop Hypertension eating plan affects C-reactive protein, coagulation abnormalities, and hepatic function tests among type 2 diabetic patients.
Study Goal
The researchers aimed to evaluate the effects of the DASH diet, which includes low-fat dairy, on inflammation, coagulation, and liver function in type 2 diabetic patients.
Results Summary
The DASH diet, rich in low-fat dairy, significantly reduced CRP levels, liver aminotransferases, and plasma fibrinogen compared to the control diet, indicating reduced inflammation and improved liver function.
Population
Type 2 diabetic patients (n=31)
Effective Dosage
Not specified (DASH diet included low-fat dairy as part of a broader dietary pattern)
Duration
8 weeks per diet phase, with a 4-week washout
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
DASH diet | decrease | plasma CRP level | type 2 diabetic patients | -26.9 ± 3.5% | reduced | #1 |
control diet | decrease | plasma CRP level | type 2 diabetic patients | -5.1 ± 3.8% | reduced | #2 |
DASH diet | decrease | alanine aminotransferase level | type 2 diabetic patients | -14.8 ± 3.0% | decreased | #3 |
control diet | decrease | alanine aminotransferase level | type 2 diabetic patients | -6.6 ± 3.4% | decreased | #4 |
DASH diet | decrease | aspartate aminotransferase level | type 2 diabetic patients | -29.4 ± 3.7% | decreased | #5 |
control diet | decrease | aspartate aminotransferase level | type 2 diabetic patients | -5.9 ± 1.4% | decreased | #6 |
DASH diet | decrease | plasma fibrinogen level | type 2 diabetic patients | -11.4 ± 3.6% | decreased | #7 |
control diet | no change | plasma fibrinogen level | type 2 diabetic patients | 0.5 ± 3.4% | changed | #8 |
DASH diet | decrease | inflammation | diabetic patients | - | can play an important role in reducing | #9 |
DASH diet | decrease | plasma levels of fibrinogen | diabetic patients | - | can play an important role in reducing | #10 |
DASH diet | decrease | liver aminotransferases | diabetic patients | - | can play an important role in reducing | #11 |
Few studies exist regarding the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on novel cardiovascular risk factors among type 2 diabetic patients. We evaluated the effects of the DASH eating pattern on C-reactive protein (CRP) level, coagulation abnormalities, and hepatic function tests in type 2 diabetic patients. In this randomized, crossover clinical trial, 31 type 2 diabetic patients consumed a control diet or the DASH diet for 8 wk. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/d sodium. The control diet was a standard diet for diabetic patients. There was a 4-wk washout between the 2 trial phases. The main outcome measures were CRP level, coagulation indices, and hepatic function tests. The mean percent change for plasma CRP level was -26.9 ± 3.5% after the DASH diet period and -5.1 ± 3.8% after the control diet period (P = 0.02). Decreases in both alanine aminotransferase and aspartate aminotransferase levels were greater after consuming the DASH diet compared with the control diet (-14.8 ± 3.0% vs -6.6 ± 3.4%; P = 0.001; -29.4 ± 3.7% vs -5.9 ± 1.4%; P = 0.001, respectively). The decrease in the plasma fibrinogen level during the DASH diet period (-11.4 ± 3.6%) was greater than that during the control diet (0.5 ± 3.4%) (P = 0.03). Among diabetic patients, the DASH diet can play an important role in reducing inflammation, plasma levels of fibrinogen, and liver aminotransferases. Future longer term studies are recommended.