Current indications for prevention and therapy of steroid-iduced osteoporosis in men and women.
Study Goal
The researchers aimed to evaluate the role of calcium supplementation in managing steroid-induced osteoporosis, particularly in preventing bone fractures.
Results Summary
The study suggests that calcium, along with vitamin D3, is part of the treatment mode for steroid-induced osteoporosis, helping to counteract negative bone balance caused by glucocorticosteroids. However, the abstract does not provide specific data on calcium's efficacy compared to other treatments like bisphosphonates.
Population
Patients on chronic steroid therapy at risk of steroid-induced osteoporosis.
Effective Dosage
Adequate doses (specific amount not mentioned).
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Glucocorticosteroids | decrease | bone formation | - | - | suppress | #1 |
Glucocorticosteroids | increase | bone resorption | - | - | increasing | #2 |
chronic steroid therapy | increase | asymptomatic bone fractures | patients | approximately 50% | undergo | #3 |
minimising the dose of administered steroids | decrease | steroid-induced osteoporosis | - | - | treatment mode includes | #4 |
improved lifestyle | decrease | steroid-induced osteoporosis | - | - | treatment mode includes | #5 |
supplementation with adequate calcium and vitamin D3 doses | decrease | steroid-induced osteoporosis | - | - | treatment mode includes | #6 |
Bisphosphonates | decrease | steroid-induced osteoporosis | - | - | used both to prevent and treat | #7 |
Steroid-induced osteoporosis is a textbook example of the secondary type of this medical condition. Glucocorticosteroids suppress bone formation by their direct and indirect effect on osteoblasts, osteoclasts and osteocytes, increasing their resorption and, eventually, leading to negative bone balance. A clinical problem arises regarding the fact that approximately 50% of patients on chronic steroid therapy undergo asymptomatic bone fractures. The treatment mode includes minimising the dose of administered steroids, encouraging an improved lifestyle and supplementation with adequate calcium and vitamin D3 doses. Bisphosphonates are a group of medical agents used both to prevent and treat steroid-induced osteoporosis, although new therapies have also become available in recent years.