Psychopharmacological effects of pyritinol in normal volunteers.
Study Goal
The researchers aimed to determine whether Pyritinol improves cognitive performance, specifically assessing Critical Flicker Fusion (CFFT), Choice Reaction Time (CRT), memory, and subjective drug effects in healthy volunteers.
Results Summary
Pyritinol significantly improved CFFT and CRT but showed no significant effects on memory or subjective drug effects. The observed cognitive enhancements were attributed to the drug, though the study was limited by a small sample size and short duration.
Population
Twelve healthy male volunteers.
Effective Dosage
600 mg or 1,200 mg per day for 3 days.
Duration
3 days per treatment period.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
pyritinol 600 or 1,200 mg | increase | Critical Flicker Fusion (CFFT) | Twelve healthy male volunteers | - | Significant improvements | #1 |
pyritinol 600 or 1,200 mg | increase | Choice Reaction Time (CRT) | Twelve healthy male volunteers | - | Significant improvements | #2 |
pyritinol 600 or 1,200 mg | no change | tests of memory | Twelve healthy male volunteers | - | no significant differences | #3 |
pyritinol 600 or 1,200 mg | no change | subjective drug effects | Twelve healthy male volunteers | - | no significant differences | #4 |
Twelve healthy male volunteers received pyritinol 600 or 1,200 mg or placebo for 3 days according to a randomised, double-blind crossover design. On the 1st and 3rd days of each of the three treatment periods subjects completed a battery of psychological tests including Critical Flicker Fusion (CFFT), Choice Reaction Time (CRT), tests of memory and subjective drug effects at 1, 2, 4 and 6 h after dosing. Significant improvements in CFFT and CRT were found after pyritinol. There were no significant differences on the other tests, however, the observed enhancement in performance could be attributed to the effect of the drug.