Vitamin D supplementation in adults - guidelines.
Study Goal
The researchers aimed to evaluate the role of vitamin D in calcium and phosphate homeostasis and its broader physiological effects, including implications for deficiency-related diseases.
Results Summary
The study highlights that vitamin D deficiency is widespread and linked to various health issues, including osteomalacia, fractures, and chronic diseases. It recommends higher daily vitamin D intake (800-1,000 U/day) for adults with inadequate sun exposure, particularly in certain populations.
Population
Healthy subjects globally, with specific focus on those avoiding sunlight and individuals over 65 years old.
Effective Dosage
800-1,000 U/day for adults with inadequate sun exposure.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | appropriate calcium and phosphate homeostasis | the body | - | is necessary in maintaining | #1 |
Vitamin D | neutral | many tissues, organs and cells | - | - | ensuring appropriate functioning of | #2 |
Vitamin D deficiency | increase | osteomalacia | adults | - | may cause | #3 |
Vitamin D deficiency | increase | fracture risk | adults with osteoporosis | - | increase | #4 |
Vitamin D deficiency | increase | cardiovascular diseases | adults | - | induce | #5 |
Vitamin D deficiency | increase | diabetes type 1 and 2 | adults | - | induce | #6 |
Vitamin D deficiency | increase | multiple sclerosis | adults | - | induce | #7 |
Vitamin D deficiency | increase | Lesniowski-Crohn disease | adults | - | induce | #8 |
Vitamin D deficiency | increase | cancer, including colon, breast, and prostate cancer | adults | - | induce | #9 |
Daily vitamin D dose, as determined by the Food and Nutrition Board in 1997 | decrease | vitamin D levels | - | - | is now rather insufficient | #10 |
maximal vitamin D levels (50 μg/day) in actually available food supplements | neutral | vitamin D levels | - | 50 μg/day | the biggest problem being associated with | #11 |
a minimum of 800-1,000 U/day | increase | vitamin D intake | adults with inadequate sun exposure (in Poland from October to April) | 800-1,000 U/day | is recommended | #12 |
This dosage (800-1,000 U/day) | decrease | anti-fracture effects | subjects who avoid sunlight and those aged over 65 | - | should be provided for | #13 |
This dosage (800-1,000 U/day) | decrease | anti-fall effects | subjects who avoid sunlight and those aged over 65 | - | should be provided for | #14 |
Vitamin D is necessary in maintaining appropriate calcium and phosphate homeostasis in the body (classical function) and ensuring appropriate functioning of many tissues, organs and cells, unrelated to mineral economy (non-classical function). Vitamin D deficiency in adults may cause osteomalacia, increase fracture risk in osteoporosis, induce cardiovascular diseases, diabetes type 1 and 2, multiple sclerosis, Lesniowski-Crohn disease, and cancer, including colon, breast, and prostate cancer. Possible causes of vitamin D deficiency in a healthy population include decreased cutaneous synthesis and an inadequate intake of vitamin D, both in food and in supplements. Vitamin D deficiency level (25(OH) D. 〈 20 ng/mL), is fairly widespread, being found in a substantial percentage of healthy subjects around the world, regardless of race, gender and age. Daily vitamin D dose, as determined by the Food and Nutrition Board in 1997, is now rather insufficient, the biggest problem being associated with maximal vitamin D levels (50 μg/day) in actually available food supplements. Nowadays, it is recommended that adults need a minimum of 800-1,000 U/day when their exposure to the sun is inadequate (in Poland from October to April). This dosage should be provided to all subjects who avoid sunlight, as well as to those aged over 65 because of their slower skin synthesis of vitamin D and for its proven anti-fracture and anti-fall effects.