Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice.
Study Goal
To evaluate the effect of mandarin juice supplementation (high in antioxidants) on oxidative stress biomarkers in severely obese children following a hypocaloric diet.
Results Summary
The supplemented group showed significant reductions in oxidative stress markers (malondialdehyde and carbonyl groups) and increases in antioxidant levels (α-tocopherol, glutathione, and vitamin C).
Population
Forty severely obese children
Effective Dosage
500 mL of 100% mandarin juice daily
Duration
4 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
supplementing a hypocaloric diet with mandarin juice | decrease | levels of malondialdehyde | obese children | -9.6% | experienced a decrease | #1 |
supplementing a hypocaloric diet with mandarin juice | decrease | levels of carbonyl groups | obese children | -36.1% | experienced a decrease | #2 |
supplementing a hypocaloric diet with mandarin juice | increase | levels of α-tocopherol | obese children | +16.1% | experienced an increase | #3 |
supplementing a hypocaloric diet with mandarin juice | increase | levels of glutathione | obese children | +36.1% | experienced an increase | #4 |
supplementing a hypocaloric diet with mandarin juice | increase | levels of vitamin C | obese children | +94.6% | experienced an increase | #5 |
mandarin juice consumption with a reduced calorie diet | increase | antioxidant defence | obese children | - | positively affects | #6 |
mandarin juice consumption with a reduced calorie diet | decrease | biomarkers of oxidative stress | obese children | - | produces a decrease | #7 |
AIM: To evaluate the effect of supplementing a hypocaloric diet with mandarin juice, a food with a high content of antioxidants (vitamin C, flavonoids and carotenoids), on biomarkers of oxidant/antioxidant status of severe obese children. METHODS: Forty obese children were randomized into two groups pair-wise in a 4-week controlled intervention study. Both groups followed a hypocaloric diet. One group received additionally a supplementation of 500mL of 100% mandarin juice daily. Clinical data, anthropometry, dietary intake and fasting blood samples were collected at baseline and after the intervention. Lipid peroxidation was assessed by circulating levels of malondialdehyde, and protein oxidation was determined by the concentration of plasma carbonyl groups. The antioxidant defence was evaluated by red cell-reduced glutathione and plasma levels of α-tocopherol and vitamin C. RESULTS: The supplemented group experienced a decrease in the levels of malondialdehyde (-9.6%, p =0.014) and carbonyl groups (-36.1%, p =0.006) and an increase in antioxidants (α-tocopherol +16.1%, p=0.006, glutathione +36.1%, p < 0.0001, and vitamin C + 94.6%, p < 0.0001). CONCLUSION: The mandarin juice consumption with a reduced calorie diet positively affects the antioxidant defence and produces a decrease in biomarkers of oxidative stress in obese children.