Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial.
Study Goal
The researchers aimed to determine the effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in young individuals with hypovitaminosis D.
Results Summary
The supplemented group showed significant improvements in handgrip strength, gastro-soleus strength, and walking distance compared to the placebo group, though muscle energy parameters remained unchanged. Cholecalciferol supplementation at 60,000 IU per month did not maintain sufficient 25(OH)D levels.
Population
Forty healthy young volunteers (24 males, 16 females; mean age 31.5 ± 5.0 years) with hypovitaminosis D.
Effective Dosage
1 g of elemental calcium daily alongside cholecalciferol (60,000 IU/week for 8 weeks, then 60,000 IU/month for 4 months).
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
cholecalciferol and calcium supplementation | increase | handgrip strength | young individuals with hypovitaminosis D | 2.4 kg (95% C.I. = 1.2-3.6) | gained | #1 |
cholecalciferol and calcium supplementation | increase | gastro-soleus strength | young individuals with hypovitaminosis D | 3.0 Nm (95% C.I. = 0.1-5.9) | gained | #2 |
cholecalciferol and calcium supplementation | increase | walking distance | young individuals with hypovitaminosis D | 15.9 m (95% C.I. = 6.3-25.5) | gained | #3 |
cholecalciferol and calcium supplementation | no change | muscle energy parameters | young individuals with hypovitaminosis D | - | were comparable | #4 |
cholecalciferol and calcium supplementation | increase | skeletal muscle strength | young individuals with hypovitaminosis D | - | results in enhanced | #5 |
cholecalciferol and calcium supplementation | increase | physical performance | young individuals with hypovitaminosis D | - | results in enhanced | #6 |
cholecalciferol supplementation of 60,000 IU per month | decrease | 25(OH)D levels in the sufficient range | young individuals with hypovitaminosis D | - | could not maintain | #7 |
CONTEXT: Vitamin D deficiency is prevalent worldwide. Vitamin D supplementation has shown variable effect on skeletal muscle strength in the elderly with hypovitaminosis D. There is a paucity of similar data in young individuals. OBJECTIVE: To study the effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in young individuals. SUBJECTS: Forty healthy volunteers (24 M/16 F, mean age (SD) 31.5 ± 5.0 year) with hypovitaminosis D were randomized to either oral cholecalciferol (60,000 IU D3/week for 8 weeks followed by 60,000 IU/month for 4 months) with 1 g of elemental calcium daily or dual placebos for 6 months. MEASUREMENTS: Handgrip and gastro-soleus dynamometry, pinch-grip strength, respiratory pressures, 6-min walk-test and muscle energy metabolism on (31) P magnetic resonance spectroscopy were assessed at baseline and after 6 months. RESULTS: The mean serum 25(OH)D in the supplemented and placebo groups at baseline, two and 6 months were 25.4 ± 9.9, 94.5 ± 53.8 and 56.0 ± 17.0 nm, and 21.1 ± 9.4, 32.8 ± 14.4 and 29.7 ± 15.0 nm, respectively. The supplemented group gained a handgrip strength of 2.4 kg (95% C.I. = 1.2-3.6); gastro-soleus strength of 3.0 Nm (95% C.I. = 0.1-5.9) and walking distance of 15.9 m (95% C.I. = 6.3-25.5) over the placebo group after adjustment for age, gender and respective baseline parameters. Muscle energy parameters were comparable at 6 months. CONCLUSIONS: Six months of cholecalciferol and calcium supplementation results in enhanced skeletal muscle strength and physical performance despite no change in muscle energy parameters. Cholecalciferol supplementation of 60,000 IU per month could not maintain 25(OH)D levels in the sufficient range.