Mortality in celiac disease.
Study Goal
The researchers aimed to evaluate mortality rates in different forms of celiac disease and assess the role of protective factors, including adherence to a gluten-free diet.
Results Summary
The study found that mortality rates for celiac disease vary by region and correlate with national gluten consumption, suggesting that gluten intake before and after diagnosis may influence outcomes. Adherence to a gluten-free diet was identified as a potential protective factor.
Population
Individuals with celiac disease, including symptomatic, unrecognized, dermatitis herpetiformis, and refractory forms.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
adherence to a gluten-free diet | decrease | mortality rate | celiac disease | - | possible protective factor | #1 |
early diagnosis | decrease | mortality rate | celiac disease | - | possible protective factor | #2 |
severity of clinical presentation | decrease | mortality rate | celiac disease | - | possible protective factor | #3 |
national gluten consumption | increase | mortality rate | celiac disease | - | correlates with | #4 |
amount of gluten consumed after diagnosis | increase | mortality rate | celiac disease | - | links to | #5 |
amount of gluten consumed before diagnosis | increase | mortality rate | celiac disease | - | links to | #6 |
Although the prevalence rates of celiac disease tend to be very similar in different Western populations, mortality rates for this disease vary widely. In this Review we focus on the papers that have addressed this issue so far. We evaluated mortality rates in different forms of celiac disease, such as symptomatic celiac disease, unrecognized celiac disease, dermatitis herpetiformis and refractory celiac disease. We also evaluated the role of possible protective factors, such as adherence to a gluten-free diet, early diagnosis and severity of clinical presentation. Finally, we noticed that the mortality rate for celiac disease seems to be higher in Southern than in Northern Europe and seems to correlate with 'national' gluten consumption. To explain these differences, we propose a hypothesis that links mortality rates to the amount of gluten consumed not only after but also before the diagnosis of celiac disease.