Effects of oral creatine and resistance training on serum myostatin and GASP-1.
Study Goal
The researchers aimed to determine the effect of 8-week resistance training combined with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and GASP-1.
Results Summary
Resistance training significantly decreased serum myostatin and increased GASP-1 levels. Creatine supplementation further reduced myostatin but did not affect GASP-1, amplifying muscle mass gains.
Population
27 healthy male subjects (23.42±2.2 years)
Effective Dosage
Not specified
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
resistance training | decrease | serum levels of myostatin | 27 healthy male subjects (23.42+/-2.2 years) | - | caused significant decrease | #1 |
resistance training | increase | serum levels of GASP-1 | 27 healthy male subjects (23.42+/-2.2 years) | - | increase | #2 |
creatine supplementation in conjunction with resistance training | decrease | serum myostatin | 27 healthy male subjects (23.42+/-2.2 years) | - | lead to greater decreases | #3 |
creatine supplementation in conjunction with resistance training | no change | GASP-1 | 27 healthy male subjects (23.42+/-2.2 years) | - | had not additional effect | #4 |
resistance training | increase | muscle mass | 27 healthy male subjects (23.42+/-2.2 years) | - | increased | #5 |
creatine supplementation | increase | muscle mass | 27 healthy male subjects (23.42+/-2.2 years) | - | amplified | #6 |
Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.